Effect of botulinum toxin type A in functionality, synkinesis and quality of life in peripheral facial palsy sequelae

U. Díaz-Aristizabal, M. Valdés-Vilches, T.R. Fernández-Ferreras, E. Calero-Muñoz, E. Bienzobas-Allué, L. Aguilera-Ballester, J. Carnicer-Cáceres
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引用次数: 1

Abstract

Objectives

This study aimed to assess the effects of botulinum toxin A (BTX-A) infiltration on face muscle function, synkinesis, and quality of life in patients with sequelae of peripheral facial palsy (PFP).

Material and methods

We present the results of a prospective study including a sample of 20 patients with sequelae of PFP (15 women, 5 men) who underwent BTX-A (Botox© or Xeomin©) infiltration. All patients had previously received personalised treatment with neuromuscular retraining. A clinical assessment was performed before BTX-A infiltration and 4 weeks after treatment. The effect of BTX-A on face muscle function, quality of life, and synkinesis was evaluated using the Sunnybrook Facial Grading System (SFGS), the Facial Clinimetric Evaluation (FaCE) questionnaire, and the Synkinesis Assessment Questionnaire (SAQ), respectively.

Results

Mean SFGS scores increased from 64.8 to 69.9 after BTX-A infiltration (P = .004). Increases were also observed in mean total FaCE scores (from 52.42 to 64.5; P < .001) and the mean score on the FaCE social function subscale (from 61.15 to 78.44; P < .001). Mean SAQ scores decreased from 46.22 to 37.55 after BTX-A infiltration (P = .001).

Conclusions

BTX-A infiltration increases face muscle function, improves quality of life, and reduces synkinesis in patients with sequelae of PFP.

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A型肉毒杆菌毒素对周围性面神经麻痹后遗症患者功能、联合运动和生活质量的影响。
目的:本研究旨在评估A型肉毒杆菌毒素(BTX-A)浸润对周围性面瘫(PFP)后遗症患者面部肌肉功能、联合运动和生活质量的影响。材料和方法:我们介绍了一项前瞻性研究的结果,包括20名PFP后遗症患者(15名女性,5名男性)的样本,这些患者接受了BTX-a(肉毒杆菌毒素©或Xeomin©)浸润。所有患者都曾接受过神经肌肉再训练的个性化治疗。在BTX-A浸润前和治疗后4周进行临床评估。分别使用Sunnybrook面部分级系统(SFGS)、面部临床评估问卷(face)和运动机能综合评估问卷(SAQ)评估BTX-A对面部肌肉功能、生活质量和联合运动的影响。结果:BTX-A浸润后,平均SFGS评分从64.8分增加到69.9分(P=.004)。平均总FaCE评分也有所增加(从52.42分增加到64.5分;P结论:在PFP后遗症患者中,BTX-A渗透可增强面部肌肉功能,提高生活质量,并减少联带形成。
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