Bilateral Association Between Atopic Dermatitis® and Alopecia Areata: A Systematic Review and Meta-Analysis.

IF 4 3区 医学 Q1 DERMATOLOGY Dermatitis Pub Date : 2024-05-01 Epub Date: 2023-07-20 DOI:10.1089/derm.2023.0114
Rong Sun, Deqi Kong
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Abstract

This systematic review and meta-analysis aimed to explore the association between atopic Dermatitis® (AD) and alopecia areata (AA). A comprehensive search was conducted in PubMed, Embase, Cochrane, and Web of Science from the inception of each database to November 10, 2022 for relevant studies. As there is a potential bilateral association between the 2 diseases, we assessed the prevalence/incidence of AA in patients with AD and the prevalence/incidence of AD in patients with AA. A total of 29 studies involving 11,233,448 participants were included in this analysis. AA was the exposure factor in 23 studies, AD in 7 studies, and both in 1 study. The meta-analysis revealed that the prevalence of AD was 11.2% (7.7%-15.1%) in patients with AA, and the prevalence of AA was 3.2% (95% confidence interval [CI]: 0.0%-11.5%) in patients with AD. The incidence of AD in AA patients was found to vary with age (P = 0.07). Based on 7 studies, there was a significant association between AD and AA when AA was the exposure factor [odds ratio, OR, = 4.537 (95% CI: 2.409-8.544)]; based on 10 studies, there was also a significant association between AD and AA when AD was the exposure factor [OR = 2.643 (95% CI: 1.737-3.995)]. In conclusion, this meta-analysis demonstrated the 2-way association between AD and AA, providing a clinical reference for disease prevention and control.

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特应性皮炎®与脱发之间的双侧关联:系统回顾和元分析。
本系统综述和荟萃分析旨在探讨特应性皮炎®(AD)与斑秃(AA)之间的关联。从 PubMed、Embase、Cochrane 和 Web of Science 数据库建立之初到 2022 年 11 月 10 日,我们对相关研究进行了全面检索。由于这两种疾病之间存在潜在的双边关联,我们评估了AD患者中AA的患病率/发病率以及AA患者中AD的患病率/发病率。本次分析共纳入了 29 项研究,涉及 11,233,448 名参与者。在 23 项研究中,AA 是暴露因素;在 7 项研究中,AD 是暴露因素;在 1 项研究中,两者都是暴露因素。荟萃分析显示,AA患者中AD的发病率为11.2%(7.7%-15.1%),AA患者中AA的发病率为3.2%(95%置信区间[CI]:0.0%-11.5%)。AA患者的AD发病率随年龄而变化(P = 0.07)。根据 7 项研究,当 AA 为暴露因素时,AD 与 AA 之间存在显著关联[几率比 OR = 4.537(95% CI:2.409-8.544)];根据 10 项研究,当 AD 为暴露因素时,AD 与 AA 之间也存在显著关联[OR = 2.643(95% CI:1.737-3.995)]。总之,这项荟萃分析证明了 AD 与 AA 之间的双向关联,为疾病防治提供了临床参考。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Dermatitis
Dermatitis 医学-皮肤病学
CiteScore
5.30
自引率
11.50%
发文量
251
审稿时长
>12 weeks
期刊介绍: Dermatitis is owned by the American Contact Dermatitis Society and is the home journal of 4 other organizations, namely Societa Italiana di Dermatologica Allergologica Professionale e Ambientale, Experimental Contact Dermatitis Research Group, International Contact Dermatitis Research Group, and North American Contact Dermatitis Group. Dermatitis focuses on contact, atopic, occupational, and drug dermatitis, and welcomes manuscript submissions in these fields, with emphasis on reviews, studies, reports, and letters. Annual sections include Contact Allergen of the Year and Contact Allergen Alternatives, for which papers are chosen or invited by the respective section editor. Other sections unique to the journal are Pearls & Zebras, Product Allergen Watch, and news, features, or meeting abstracts from participating organizations.
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