Jiagui Chai, Sifan Yin, Wenbo Feng, Tao Zhang, Changxing Ke
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引用次数: 0
Abstract
Bladder cancer (BC) is one of the most common malignant tumors worldwide and poses a significant hazard to human health. During the development of BC, hypoxia plays a crucial role. Hypoxia-inducible factor (HIF) is a key transcription factor for hypoxic adaptation, which regulates the transcription of various genes, including inflammation, angiogenesis, and glycolytic metabolism. Recent studies have shown the precise role of HIF in various biological behaviors of BC. More importantly, a new antitumor medication targeting HIF-2 has been used to treat renal cancer. However, therapies targeting HIF-1 in BC have not yet been developed. In this review, we discussed how HIF-1 is expressed and affects the growth, metastasis, and angiogenesis of BC. At the same time, we investigated several HIF-1 inhibitors that provide new perspectives for targeting HIF-1.
膀胱癌（BC）是全球最常见的恶性肿瘤之一，对人类健康构成重大危害。在膀胱癌的发展过程中，缺氧起着至关重要的作用。低氧诱导因子（HIF）是低氧适应的关键转录因子，可调控炎症、血管生成和糖代谢等多种基因的转录。最近的研究表明，HIF 在 BC 的各种生物学行为中发挥着精确的作用。更重要的是，一种靶向 HIF-2 的新型抗肿瘤药物已被用于治疗肾癌。然而，针对 BC 中 HIF-1 的疗法尚未开发出来。在这篇综述中，我们讨论了 HIF-1 如何表达并影响 BC 的生长、转移和血管生成。同时，我们研究了几种HIF-1抑制剂，它们为靶向HIF-1提供了新的视角。
期刊介绍：
Current Molecular Medicine is an interdisciplinary journal focused on providing the readership with current and comprehensive reviews/ mini-reviews, original research articles, short communications/letters and drug clinical trial studies on fundamental molecular mechanisms of disease pathogenesis, the development of molecular-diagnosis and/or novel approaches to rational treatment. The reviews should be of significant interest to basic researchers and clinical investigators in molecular medicine. Periodically the journal invites guest editors to devote an issue on a basic research area that shows promise to advance our understanding of the molecular mechanism(s) of a disease or has potential for clinical applications.
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