Effect of Tomato (Solanum lycopersicum) Extract in Patients with Primary Insomnia: A Double-blind Randomized Study.

Q3 Psychology Central nervous system agents in medicinal chemistry Pub Date : 2023-01-01 DOI:10.2174/1871524923666230720155754

Parvin Dehnavi, Hassan Rakhshandeh, Elham Bakhtiari, Hadi Asadpour, Seyed Mostafa Moshirian Farahi, Fatemeh Forouzanfar

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Abstract

Objective: Insomnia is a condition that causes sleep problems, and many people suffer from it. Patients with this disorder have difficulty with beginning or continuation of sleep, so they are exhausted all day long, and their performance reduces. This study was designed to assess the efficacy of capsules that contain tomato extract in patients with primary insomnia.

Methods: In this study, 70 patients with primary insomnia were assigned to 2 groups randomly: intervention and control. The intervention group used to take tomato capsules every night for 2 weeks, and the placebo one used to take placebo capsules every night for 2 weeks. All patients used to fill out Insomnia Severity Index (ISI) and Pittsburgh Sleep Quality Index (PSQI) questionnaires before and after the intervention. ISI and PSQI results were analyzed separately on SPSS software.

Results: A total of 70 patients (35 in the intervention group and 35 in the control group), including 50 females and 20 males, were studied. Female to male ratio and the rate of unemployment were significantly higher in the intervention group (in both cases P < 0.001), but there was no significant difference between the intervention and control groups in other characteristics (Age, marital status, weight, height, education; in all cases P > 0.05). At the end of the study, the amount of actual sleep had increased, and the delay in falling asleep decreased in both groups; the two groups at the end of the study were not significantly different in terms of these two variables (P > 0.05). The ISI score in both groups decreased significantly at the end of the study, and the PSQI score in both groups decreased significantly at the end of the study (In both cases, P < 0.05). The absolute value of ISI score change in the intervention group was significantly higher than the control group (P < 0.001); But the absolute value of PSQI score change was not significantly different between the two groups (P = 0.102). Most importantly, the improvement of both ISI and PSQI scores in the intervention group was significantly better than the control group (P > 0.05).

Conclusion: This study showed that tomato capsules have sleep-inducing effects, although there was no significant difference in the amount of actual sleep, and the delay in falling sleep in the intervention group compared to the control group.

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番茄提取物对原发性失眠患者的影响：一项双盲随机研究。

目的：失眠是一种导致睡眠问题的疾病，许多人都患有失眠。失眠患者很难开始或继续睡眠，因此他们整天都很疲惫，表现也会下降。本研究旨在评估含有番茄提取物的胶囊对原发性失眠患者的疗效。方法：将70例原发性失眠患者随机分为干预组和对照组。干预组每晚服用番茄胶囊，持续2周，安慰剂组每晚服用安慰剂胶囊，持续两周。所有患者在干预前后分别填写失眠严重程度指数（ISI）和匹兹堡睡眠质量指数（PSQI）问卷。ISI和PSQI结果分别在SPSS软件上进行分析。结果：共研究了70例患者（干预组35例，对照组35例），其中女性50例，男性20例。干预组的男女比例和失业率显著较高（两种情况下均<0.001），但干预组和对照组在其他特征（年龄、婚姻状况、体重、身高、教育程度；所有情况下均P>0.05）上没有显著差异，两组患者入睡延迟均有所减少；两组在这两个变量方面研究结束时差异无统计学意义（P>0.05）。两组的ISI评分在研究结束时均显著下降，两组的PSQI评分在研究结束时均显著下降（两组均P<0.05）。干预组ISI评分变化的绝对值显著高于对照组（P<0.001）；但两组PSQI评分变化的绝对值差异无统计学意义（P=0.102）。最重要的是，干预组ISI和PSQI评分的改善均明显优于对照组（P>0.05），尽管干预组的实际睡眠量和入睡延迟与对照组相比没有显著差异。

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来源期刊

Central nervous system agents in medicinal chemistry Psychology-Neuropsychology and Physiological Psychology

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2.10

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0.00%

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期刊介绍： Central Nervous System Agents in Medicinal Chemistry aims to cover all the latest and outstanding developments in medicinal chemistry and rational drug design for the discovery of new central nervous system agents. Containing a series of timely in-depth reviews written by leaders in the field covering a range of current topics, Central Nervous System Agents in Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments in the field.