Glucocorticoid Receptor Polymorphisms and Avascular Osteonecrosis After Kidney Transplantation.

IF 0.8 4区医学 Q4 UROLOGY & NEPHROLOGY Iranian journal of kidney diseases Pub Date : 2023-03-01

Jalal Etemadi, Mohammad Reza Jafari Nakhjavani, Saber Sepehri, Roza Motavalli, Seyed Sina Hejazian, Seyyedeh Mina Hejazain, Sima Abediazar, Sepideh Zununi Vahed

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Abstract

Introduction: Glucocorticoids (GCs) are commonly prescribed as immunosuppressive agents after kidney transplantation and their most common non-traumatic adverse effect is Avascular Necrosis (AVN) of the femoral head. In this regard, this study aimed to evaluate the glucocorticoid receptor (GR) polymorphisms among kidney transplant recipients and their potential role as a risk factor for the incidence of AVN.

Methods: In this study, 99 renal transplant recipients were evaluated for the correlations of GR polymorphisms including N363S (rs6195), BclI (rs41423247), ER22/23EK (rs6189/rs6190), and A3669G (rs6198) with AVN after renal transplantation.

Results: Results showed that none of the renal-transplanted patients neither with GC hypersensitive polymorphisms (N363S and BclI) nor with GC-resistant polymorphisms (A3669G and ER22/23EK) developed AVN (P > .05). In addition, the medications of the renal recipients with AVN were significantly different from the nonAVN patients (P < .001).

Conclusion: The study results indicate that the GR polymorphisms have no critical roles in the susceptibility to AVN after renal transplantation. However, further studies to confirm the results are recommended. DOI: 10.52547/ijkd.7221.

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肾移植后糖皮质激素受体多态性与缺血性骨坏死。

糖皮质激素(GCs)通常作为肾移植后的免疫抑制剂，其最常见的非创伤性不良反应是股骨头的缺血性坏死(AVN)。因此，本研究旨在评估肾移植受者的糖皮质激素受体(GR)多态性及其作为AVN发生危险因素的潜在作用。方法:本研究对99例肾移植受者进行肾移植后GR多态性N363S (rs6195)、BclI (rs41423247)、ER22/23EK (rs6189/rs6190)、A3669G (rs6198)与AVN的相关性分析。结果:无GC超敏多态性(N363S和BclI)和GC耐药多态性(A3669G和ER22/23EK)肾移植患者均未发生AVN (P > 0.05)。此外，肾移植患者与非肾移植患者的用药差异有统计学意义(P < 0.001)。结论:研究结果表明，GR多态性在肾移植术后AVN易感性中无关键作用。然而，建议进行进一步的研究来证实这一结果。DOI: 10.52547 / ijkd.7221。

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来源期刊

Iranian journal of kidney diseases UROLOGY & NEPHROLOGY-

CiteScore

2.50

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： The Iranian Journal of Kidney Diseases (IJKD), a peer-reviewed journal in English, is the official publication of the Iranian Society of Nephrology. The aim of the IJKD is the worldwide reflection of the knowledge produced by the scientists and clinicians in nephrology. Published quarterly, the IJKD provides a new platform for advancement of the field. The journal’s objective is to serve as a focal point for debates and exchange of knowledge and experience among researchers in a global context. Original papers, case reports, and invited reviews on all aspects of the kidney diseases, hypertension, dialysis, and transplantation will be covered by the IJKD. Research on the basic science, clinical practice, and socio-economics of renal health are all welcomed by the editors of the journal.