Phytochemical characterization, antioxidant and antibacterial activities of crude extracts of Anisomeles malabarica and Coldenia procumbens.

IF 2.3 4区 医学 Q3 ENVIRONMENTAL SCIENCES Journal of Toxicology and Environmental Health-Part A-Current Issues Pub Date : 2023-09-02 Epub Date: 2023-07-03 DOI:10.1080/15287394.2023.2231484
Ramalingam Revathi, R Akash, Ramasamy Mahadevi, Singaravel Sengottuvelu, Palanisamy Mohanraj, Natesan Vijayakumar, Rajapandiyan Krishnamoorthy, Mohammad Z Ahmed, Shadab Kazmi, Ramamoorthy Kavitha
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引用次数: 1

Abstract

The aim of this study was to determine the phytochemical profile, antibacterial and antioxidant activities of crude aqueous leaf extracts of Anisomeles malabarica and Coldenia procumbens. The predominant components present in these crude extracts of test plants identified using gas chromatography-mass spectrometry (GC-MS) analysis in both plant extracts were phytochemicals including flavonoids, tannins, terpenoids, and phenols. The antibacterial activity of crude extracts of these plants against bacterial pathogens including Escherichia coli, Bacillus subtilis, Shigella sp., Salmonella paratyphi A and B, Proteus mirabilis, Proteus vulgaris, Pseudomonas sp. Klebsiella pneumoniae, and Staphylococcus aureus were examined. Data demonstrated that the extracts of A. malabarica and C. procumbens exhibited significant antibacterial activity against B.subtilis and P.vulgaris at the concentration of 50 mg/ml. A. malabarica aqueous extract displayed significant antioxidant activity on 2,2-diphenyl-1-picrylhydrazl (DPPH), fluorescence recovery after photobleaching (FRAP) and hydrogen peroxide (H2O2) free radicals at the concentration of 90 mg/ml. The antioxidant activity was significantly higher with A. malabarica than extract of C. procumbens. Evidence indicates that both plant extracts may possess significant pharmaceutical potential as antibacterial and antioxidant agents.

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Anisomeles malabarica 和 Coldenia procumbens 粗提取物的植物化学特征、抗氧化和抗菌活性。
本研究旨在确定 Anisomeles malabarica 和 Coldenia procumbens 的粗水叶提取物的植物化学成分、抗菌和抗氧化活性。通过气相色谱-质谱(GC-MS)分析,确定了这两种植物萃取物中的主要植物化学成分,包括黄酮类、单宁类、萜类和酚类。研究了这些植物的粗提取物对细菌病原体的抗菌活性,包括大肠杆菌、枯草杆菌、志贺氏菌、副伤寒沙门氏菌 A 和 B、变形杆菌、普通变形杆菌、假单胞菌、肺炎克雷伯氏菌和金黄色葡萄球菌。数据表明,在 50 毫克/毫升的浓度下,A. malabarica 和 C. procumbens 的提取物对枯草杆菌和普通变形杆菌具有显著的抗菌活性。在浓度为 90 毫克/毫升时,A. malabarica 水提取物对 2,2-二苯基-1-苦基肼(DPPH)、光漂白后荧光恢复(FRAP)和过氧化氢(H2O2)自由基具有明显的抗氧化活性。A. malabarica 的抗氧化活性明显高于 C. procumbens 的提取物。有证据表明,这两种植物萃取物作为抗菌剂和抗氧化剂可能具有巨大的制药潜力。
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来源期刊
CiteScore
5.20
自引率
19.20%
发文量
46
审稿时长
8-16 weeks
期刊介绍: The Journal of Toxicology and Environmental Health, Part A , Current Issues is an authoritative journal that features strictly refereed original research in the field of environmental sciences, public and occupational health, and toxicology.
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