Acute rotavirus infection causes significant activation of the IL-33/IL-13 axis.

IF 0.5 4区医学 Q4 MICROBIOLOGY Epidemiologie Mikrobiologie Imunologie Pub Date : 2023-01-01

I Paulauskaitė, R Orentaitė

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Abstract

Aim: Overactivation of the IL-33/IL-13 axis is the main step in initializing allergic inflammation and promoting allergic diseases. Data on viral pathogens as risk factors for subsequent allergic disease are contradictory. The strongest associations have been made between upper respiratory tract virus infections and asthma. Intestinal viral infections also activate IL-33 and IL-13 as part of the innate antiviral response. The aim of this study was to test whether there are differences in IL-13 and IL-33 concentrations in pediatric patients with acute rotavirus- and norovirus infections and healthy controls.

Material and methods: Forty children with acute rotavirus, 27 with acute norovirus intestinal infections and 17 control children were enrolled in this study. Blood IL-33 and IL-13 detection was performed with enzyme-linked immunosorbent assays (ELISAs).

Results: Acute rotavirus infection caused a significant elevation in IL-33 and IL-13 compared to acute norovirus infection (63.85 pg/ml vs. 0, P = 0.0026, and 94.24 pg/ml vs. 0.88 pg/ml, P = 0.0003, respectively) and healthy controls (63.85 pg/ml vs. 9.89 pg/ ml, P = 0.0018, and 94.24 pg/ml vs. 0.14 pg/ml, P < 0.0001, respectively). There was no significant difference in IL-33 and IL-13 concentrations between the acute norovirus group and healthy controls (0 vs. 9.89 pg/ml, P = 0.8276 and 0.88 pg/ml vs. 0.14 pg/ml, P = 0.1652, respectively).

Conclusion: Acute rotavirus infection causes a significant elevation in IL-33 and IL-13, compared to norovirus and healthy control children.

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急性轮状病毒感染引起IL-33/IL-13轴的显著激活。

目的:IL-33/IL-13轴的过度激活是初始化变应性炎症和促进变应性疾病的主要步骤。关于病毒性病原体作为随后过敏性疾病的危险因素的数据是相互矛盾的。上呼吸道病毒感染与哮喘之间的联系最为密切。肠道病毒感染也激活IL-33和IL-13作为先天抗病毒反应的一部分。本研究的目的是测试急性轮状病毒和诺如病毒感染的儿童患者和健康对照组中IL-13和IL-33浓度是否存在差异。材料与方法:选取急性轮状病毒感染患儿40例，急性诺如病毒肠道感染患儿27例，对照组17例。采用酶联免疫吸附法(elisa)检测血清IL-33和IL-13。结果:急性轮状病毒感染引起IL-33和IL-13显著升高，与急性诺如病毒感染(63.85 pg/ml vs. 0, P = 0.0026, 94.24 pg/ml vs. 0.88 pg/ml, P = 0.0003)和健康对照组(63.85 pg/ml vs. 9.89 pg/ml, P = 0.0018, 94.24 pg/ml vs. 0.14 pg/ml, P <分别为0.0001)。急性诺如病毒组与健康对照组IL-33、IL-13浓度差异无统计学意义(分别为0 vs. 9.89 pg/ml, P = 0.8276; 0.88 pg/ml vs. 0.14 pg/ml, P = 0.1652)。结论:与诺如病毒和健康对照相比，急性轮状病毒感染可引起IL-33和IL-13显著升高。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Epidemiologie Mikrobiologie Imunologie Medicine-Immunology and Allergy

CiteScore

0.90

自引率

0.00%

发文量

期刊介绍： The journal publishes original papers, information from practice, reviews on epidemiological and microbiological subjects. Sufficient space is devoted to diagnostic methods from medical microbiology, parasitology, immunology, and to general aspects and discussions pertaining to preventive medicine. It also brings translations and book reviews useful for medical doctors and research workers and professionals in public health.

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