Identification of crucial genes involved in thyroid cancer development.

IF 1.8 Q3 ONCOLOGY Journal of the Egyptian National Cancer Institute Pub Date : 2023-05-22 DOI:10.1186/s43046-023-00177-0

Iyshwarya Bhaskar Kalarani, Ganesan Sivamani, Ramakrishnan Veerabathiran

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引用次数: 1

Abstract

Background: A malignancy of the endocrine system, one of the most common types, is thyroid cancer. It is proven that children who receive radiation treatment for leukemia or lymphoma are at a heightened risk of thyroid cancer due to low-dose radiation exposure throughout childhood. Several factors can increase the risk of thyroid cancer (ThyCa), such as chromosomal and genetic mutations, iodine intake, TSH levels, autoimmune thyroid disorders, estrogen, obesity, lifestyle changes, and environmental contaminants.

Objectives: The study aimed to identify a specific gene as an essential candidate for thyroid cancer progression. We might be able to focus on developing a better understanding of how thyroid cancer is inherited.

Methods: The review article uses electronic databases such as PubMed, Google Scholar, Ovid MEDLINE, Embase, and Cochrane Central. The most frequently associated genes with thyroid cancer found on PubMed were BAX, XRCC1, XRCC3, XPO5, IL-10, BRAF, RET, and K-RAS. To perform an electronic literature search, genes derived from DisGeNET: a database of gene-disease associations, including PRKAR1A, BRAF, RET, NRAS, and KRAS, are used.

Conclusion: Examining the genetics of thyroid cancer explicitly emphasizes the primary genes associated with the pathophysiology of young and older people with thyroid cancer. Developing such gene investigations at the beginning of the thyroid cancer development process can identify better outcomes and the most aggressive thyroid cancers.

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鉴定与甲状腺癌发展相关的关键基因。

背景:内分泌系统的恶性肿瘤是最常见的类型之一，甲状腺癌。事实证明，接受白血病或淋巴瘤放射治疗的儿童由于在整个儿童时期受到低剂量辐射，患甲状腺癌的风险较高。有几个因素可以增加患甲状腺癌(ThyCa)的风险，如染色体和基因突变、碘摄入量、TSH水平、自身免疫性甲状腺疾病、雌激素、肥胖、生活方式改变和环境污染物。目的:该研究旨在确定一个特定基因作为甲状腺癌进展的重要候选基因。我们也许可以专注于更好地了解甲状腺癌是如何遗传的。方法:综述文章使用PubMed、Google Scholar、Ovid MEDLINE、Embase和Cochrane Central等电子数据库。在PubMed上发现的与甲状腺癌最常见的相关基因是BAX、XRCC1、XRCC3、XPO5、IL-10、BRAF、RET和K-RAS。为了进行电子文献检索，使用了来自DisGeNET的基因:一个基因与疾病相关的数据库，包括PRKAR1A、BRAF、RET、NRAS和KRAS。结论:检查甲状腺癌的遗传学明确强调了与年轻和老年甲状腺癌患者病理生理相关的主要基因。在甲状腺癌发展过程的开始阶段开展这种基因研究可以确定更好的结果和最具侵袭性的甲状腺癌。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of the Egyptian National Cancer Institute ONCOLOGY-

CiteScore

3.50

自引率

0.00%

发文量

审稿时长

11 weeks

期刊介绍： As the official publication of the National Cancer Institute, Cairo University, the Journal of the Egyptian National Cancer Institute (JENCI) is an open access peer-reviewed journal that publishes on the latest innovations in oncology and thereby, providing academics and clinicians a leading research platform. JENCI welcomes submissions pertaining to all fields of basic, applied and clinical cancer research. Main topics of interest include: local and systemic anticancer therapy (with specific interest on applied cancer research from developing countries); experimental oncology; early cancer detection; randomized trials (including negatives ones); and key emerging fields of personalized medicine, such as molecular pathology, bioinformatics, and biotechnologies.