Influence of SGLT2 Inhibitors in Remodeling, Substrate and Ion Metabolism of Myocardium to Prevent Cardiovascular Risks: Recent Work and Advancement.

IF 2.4 4区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Current molecular pharmacology Pub Date : 2023-01-01 DOI:10.2174/1874467216666221017123333

Nishant Johri, Prithpal S Matreja, Davis John, Shubham Dutta, Ashok Kumar Parida, Susanta Nath Sarma

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引用次数: 2

Abstract

Sodium-glucose cotransporter 2 (SGLT2) inhibitors are a new class of drugs that lower blood glucose levels while decreasing blood pressure, volume loss, and weight loss. SGLT2 inhibitors were studied to determine their effectiveness in treating cardiovascular disease and their side effects. Study outcomes related to cardiovascular and metabolic outcomes were examined in patients on SGLT2 inhibitors by searching PubMed, Embase, Cochrane, and SCOPUS. Articles related to clinical trials, reviews, and meta-analyses were considered. A review of SGLT2 inhibitors' mechanisms of action in preventing cardiovascular (CVS) disease progression was described. We then reviewed the possible effects of SGLT2 inhibitors on CVS dysfunction development, composition, and stability. In the following, we discussed the impact of SGLT2 inhibitors on CVD events, such as ischemic strokes and myocardial infarctions, and their role in treating congestive heart failure and cardiovascular mortality.

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SGLT2抑制剂对心肌重塑、底物和离子代谢的影响及其预防心血管风险的研究进展

钠-葡萄糖共转运蛋白2 (SGLT2)抑制剂是一类新的药物，可以降低血糖水平，同时减少血压、体积损失和体重减轻。研究SGLT2抑制剂以确定其治疗心血管疾病的有效性及其副作用。通过检索PubMed、Embase、Cochrane和SCOPUS，对SGLT2抑制剂患者的心血管和代谢相关的研究结果进行检查。我们考虑了与临床试验、综述和荟萃分析相关的文章。综述了SGLT2抑制剂在预防心血管疾病进展中的作用机制。然后，我们回顾了SGLT2抑制剂对CVS功能障碍发展、组成和稳定性的可能影响。在下文中，我们讨论了SGLT2抑制剂对CVD事件的影响，如缺血性卒中和心肌梗死，以及它们在治疗充血性心力衰竭和心血管死亡率中的作用。

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来源期刊

Current molecular pharmacology Pharmacology, Toxicology and Pharmaceutics-Drug Discovery

CiteScore

4.90

自引率

3.70%

发文量

112

期刊介绍： Current Molecular Pharmacology aims to publish the latest developments in cellular and molecular pharmacology with a major emphasis on the mechanism of action of novel drugs under development, innovative pharmacological technologies, cell signaling, transduction pathway analysis, genomics, proteomics, and metabonomics applications to drug action. An additional focus will be the way in which normal biological function is illuminated by knowledge of the action of drugs at the cellular and molecular level. The journal publishes full-length/mini reviews, original research articles and thematic issues on molecular pharmacology. Current Molecular Pharmacology is an essential journal for every scientist who is involved in drug design and discovery, target identification, target validation, preclinical and clinical development of drugs therapeutically useful in human disease.