Marjan Talebi, Tahereh Farkhondeh, Mohammad Sadra Harifi-Mood, Mohsen Talebi, Saeed Samarghandian
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引用次数: 1
Abstract
Breast cancer (BC) is accountable for a large number of female-related malignancies that lead to lethality worldwide. Various factors are considered in the occurrence of BC, including the deregulation of cancer stem cells (CSCs) and epithelial-mesenchymal transition (EMT). Genetic factors such as microRNAs (miRs) are crucially responsible for BC progression and aggressiveness. Hence, the association of miRs and EMT regulators (e.g., Wnt signaling pathway) is of importance. In the present review, we accurately discussed this interplay (interaction between Wnt and miRs) concerning cell - invasion, -migration, -differentiation, -chemoresistance, survival, and-proliferation, and BC prognosis. The putative therapeutic agents, multidrug resistance (MDR) evade, and possible molecular targets are described as well.
期刊介绍：
Current Molecular Pharmacology aims to publish the latest developments in cellular and molecular pharmacology with a major emphasis on the mechanism of action of novel drugs under development, innovative pharmacological technologies, cell signaling, transduction pathway analysis, genomics, proteomics, and metabonomics applications to drug action. An additional focus will be the way in which normal biological function is illuminated by knowledge of the action of drugs at the cellular and molecular level. The journal publishes full-length/mini reviews, original research articles and thematic issues on molecular pharmacology.
Current Molecular Pharmacology is an essential journal for every scientist who is involved in drug design and discovery, target identification, target validation, preclinical and clinical development of drugs therapeutically useful in human disease.
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