A Case of Transverse Myelitis Following Treatment with Atezolizumab for Advanced Hepatocellular Carcinoma.

IF 0.6 Q4 GASTROENTEROLOGY & HEPATOLOGY The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi Pub Date : 2023-07-25 DOI:10.4166/kjg.2023.054
Kyung Han Kim, Yang-Hyun Baek, Yeo Wool Kang, Byeol-A Yoon, Sang Yi Moon
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Abstract

The results of the IMbrave150 study have led to widespread use of the combination therapy of atezolizumab and bevacizumab as a first-line treatment for unresectable or metastatic hepatocellular carcinoma (HCC). Compared to traditional cytotoxic chemotherapy agents, immune checkpoint inhibitors show a spectrum of side effects ranging from mild side effects such as skin rash to potentially severe systemic effects such as myocarditis. We present a case of transverse myelitis diagnosed during the treatment of HCC with atezolizumab and bevacizumab combination therapy.

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阿替佐利珠单抗治疗晚期肝细胞癌后并发横贯性脊髓炎一例。
IMbrave150研究的结果已导致atezolizumab和贝伐单抗的联合治疗被广泛用作不可切除或转移性肝细胞癌(HCC)的一线治疗。与传统的细胞毒性化疗药物相比,免疫检查点抑制剂表现出一系列副作用,从轻微的副作用(如皮疹)到潜在的严重全身作用(如心肌炎)。我们报告了一例在atezolizumab和贝伐单抗联合治疗HCC期间诊断为横贯性脊髓炎的病例。
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来源期刊
CiteScore
1.20
自引率
0.00%
发文量
83
审稿时长
24 weeks
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