Hearing Loss and Blood Coagulation Disorders: A Review.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2023-07-04 DOI:10.3390/hematolrep15030043

Virginia Corazzi, Andrea Migliorelli, Chiara Bianchini, Stefano Pelucchi, Andrea Ciorba

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Abstract

A relationship between microvascular disorders and sensorineural hearing loss (SNHL) has been widely proposed. The vascular hypothesis, theorized for the onset of sudden SNHL (SSNHL), is among the most acknowledged: a localized acute cochlear damage, of ischemic or haemorrhagic nature, could be considered a causative factor of SSNHL. The aim of this review is to assess (i) the effect on hearing in patients affected by blood coagulation disorders (prothrombotic or haemorrhagic) and (ii) the possible etiopathogenetic mechanisms of the related hearing loss. A PRISMA-compliant review was performed. Medline, Embase, and Cinahl databases were searched from inception to 31 January 2023, and a total of 14 studies have been included in the review. The available data suggest that it is possible to consider clotting disorders as a potential condition at risk for sensorineural hearing loss; in particular, coagulation tests and eventually the assessment of genetic and acquired prothrombotic factors should be recommended in patients with SSNHL. Also, an audiological evaluation should be recommended for patients with blood coagulation disorders presenting cochlear symptoms, especially in those suffering from clotting diseases.

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听力损失和凝血功能障碍:综述。

微血管疾病与感音神经性听力损失(SNHL)之间的关系已被广泛提出。突发性SNHL (SSNHL)发病的血管假说是最被认可的理论之一:局部急性耳蜗损伤，缺血性或出血性，可被认为是SSNHL的致病因素。本综述的目的是评估(i)受凝血障碍(血栓前性或出血)影响的患者对听力的影响以及(ii)相关听力损失的可能致病机制。进行prisma合规审查。检索了Medline、Embase和Cinahl数据库，从开始到2023年1月31日，共有14项研究被纳入该综述。现有数据表明，可以将凝血障碍视为感音神经性听力损失的潜在风险;特别是，对于SSNHL患者，应建议进行凝血试验并最终评估遗传和获得性血栓形成因子。同时，对于出现耳蜗症状的凝血障碍患者，特别是患有凝血疾病的患者，应建议进行听力学评估。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.