¹⁶¹Tb-PSMA Unleashed: a Promising New Player in the Theranostics of Prostate Cancer.

IF 1.3 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Nuclear Medicine and Molecular Imaging Pub Date : 2023-08-01 Epub Date: 2023-04-26 DOI:10.1007/s13139-023-00804-7

Akram Al-Ibraheem, Andrew M Scott

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Abstract

Radiotheranostics with ¹⁷⁷Lu-PSMA have changed the treatment paradigm in patients with prostate cancer, becoming the new standard in certain settings. Terbium-161 (¹⁶¹Tb) has been recently investigated as a potential radionuclide for radiotheranostics in various types of cancer, including metastatic castration-resistant prostate cancer (mCRPC). The nuclear medicine team at King Hussein Cancer Center (KHCC) in Amman, Jordan, recently published the first-in-human SPECT/CT imaging results following a well-tolerated dose of ¹⁶¹Tb-PSMA radioligand therapy with no treatment-related adverse events, adding to the potential of radiotheranostics in prostate cancer. Two clinical trials for ¹⁶¹Tb-PSMA radioligand therapy in prostate cancer are currently underway and will provide valuable insights. This review will shed light on the expanding field of radiotheranostics in prostate cancer, which is not without challenges, and will discuss how the introduction of a new therapeutic option like ¹⁶¹Tb-PSMA may help to combat these challenges and build on the proven success of ¹⁷⁷Lu-PSMA-based radiotheranostics for the benefit of prostate cancer patients worldwide.

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161Tb-PSMA释放：癌症前列腺治疗领域有前途的新玩家。

177Lu-PSMA放射治疗改变了癌症患者的治疗模式，成为某些情况下的新标准。近年来，Terbium-161（161Tb）已被研究为各种类型癌症（包括转移性去势抵抗性癌症（mCRPC））的放射性核素。约旦安曼侯赛因国王癌症中心（KHCC）的核医学团队最近公布了首次人体SPECT/CT成像结果，该结果是在良好耐受剂量的161Tb-PSMA放射性配体治疗后得出的，没有治疗相关的不良事件，增加了放射疗法治疗癌症前列腺癌的潜力。161Tb-PSMA放射性配体治疗前列腺癌症的两项临床试验目前正在进行中，将提供有价值的见解。这篇综述将阐明在前列腺癌症中不断扩大的放射疗法领域，这并非没有挑战，并将讨论引入161Tb-PSMA等新的治疗方案如何有助于克服这些挑战，并在177Lu-PSMA为基础的放射疗法在全世界前列腺癌症患者带来的成功基础上再接再厉。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nuclear Medicine and Molecular Imaging RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING-

CiteScore

2.20

自引率

7.70%

发文量

期刊介绍： Nuclear Medicine and Molecular Imaging (Nucl Med Mol Imaging) is an official journal of the Korean Society of Nuclear Medicine, which bimonthly publishes papers on February, April, June, August, October, and December about nuclear medicine and related sciences such as radiochemistry, radiopharmacy, dosimetry and pharmacokinetics / pharmacodynamics of radiopharmaceuticals, nuclear and molecular imaging analysis, nuclear and molecular imaging instrumentation, radiation biology and radionuclide therapy. The journal specially welcomes works of artificial intelligence applied to nuclear medicine. The journal will also welcome original works relating to molecular imaging research such as the development of molecular imaging probes, reporter imaging assays, imaging cell trafficking, imaging endo(exo)genous gene expression, and imaging signal transduction. Nucl Med Mol Imaging publishes the following types of papers: original articles, reviews, case reports, editorials, interesting images, and letters to the editor. The Korean Society of Nuclear Medicine (KSNM) KSNM is a scientific and professional organization founded in 1961 and a member of the Korean Academy of Medical Sciences of the Korean Medical Association which was established by The Medical Services Law. The aims of KSNM are the promotion of nuclear medicine and cooperation of each member. The business of KSNM includes holding academic meetings and symposia, the publication of journals and books, planning and research of promoting science and health, and training and qualification of nuclear medicine specialists.