A Significant Association between Parathyroid Adenoma Volume and Bone Mineral Loss at Distal Forearm.

IF 1.6 Q2 MEDICINE, GENERAL & INTERNAL Romanian Journal of Internal Medicine Pub Date : 2023-07-26 Print Date: 2023-12-01 DOI:10.2478/rjim-2023-0018
Emre Gezer, Ömer Zekey, Büşra Yaprak Bayrak, Zeynep Cantürk, Berrin Çetinarslan, Alev Selek, Mehmet Sözen, Damla Köksalan
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Abstract

Introduction: The cortical bone is the most severely affected site in patients with primary hyperparathyroidism (PHPT) and thus, a low bone mineral density (BMD) is predominantly observed in distal forearm. Several studies have investigated potential associations between the weight of the gland and bone mineral loss. In this study, we wanted to investigate the relationship between parathyroid adenoma (PTA) volume and bone mineral loss.

Methods: All patients with a diagnosis of PHPT who were operated at our hospital, and with a histologically proven single PTA were retrospectively analyzed. Z-scores were used as the main variable in our analysis to eliminate the effects of age, sex and gonadal status on BMD.

Results: Total of 153 patients who met the inclusion criteria were eligible for the study. A significant negative correlation between the PTA volume and z-score for distal third of the radius (DR) (p = 0.006, r = -0.297) was shown. The cut-off value of gland volume for predicting cortical bone mineral loss was 9043.2 mm3. There was also a significant negative correlation between the 24-hour urine calcium and z-scores for lumbar vertebrae and total hip. A significant negative correlation was found between preoperative 25-hydroxy vitamin D levels and the PTA weight.

Conclusions: As the first study that evaluated any possible association between the volume of a parathyroid adenoma and bone mineral loss in patients with PHPT, we found a significant negative correlation between DR z-scores and resected gland volume. Since the volume of a PTA can also be determined by a preoperative US, our findings may be helpful during the preoperative evaluation of a patient with a preliminary diagnosis of PHPT.

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前臂远端甲状旁腺瘤体积与骨矿物质丢失的显著相关性。
在原发性甲状旁腺功能亢进(PHPT)患者中,皮质骨是受影响最严重的部位,因此,低骨密度(BMD)主要见于前臂远端。一些研究已经调查了腺体重量和骨矿物质流失之间的潜在联系。在这项研究中,我们想探讨甲状旁腺瘤(PTA)体积与骨矿物质损失的关系。方法:回顾性分析所有在我院手术诊断为PHPT并有组织学证实的单一PTA的患者。在我们的分析中,z分数被用作主要变量,以消除年龄、性别和性腺状态对骨密度的影响。结果:153例符合纳入标准的患者被纳入研究。PTA体积与桡骨远端三分之一(DR)的z-score呈显著负相关(p = 0.006, r = -0.297)。预测皮质骨矿物质丢失的腺体体积临界值为9043.2 mm3。24小时尿钙与腰椎和全髋关节z-评分之间也存在显著的负相关。术前25-羟基维生素D水平与PTA体重呈显著负相关。结论:作为第一项评估PHPT患者甲状旁腺瘤体积与骨矿物质丢失之间可能存在关联的研究,我们发现DR z-score与切除腺体体积之间存在显著的负相关。由于PTA的体积也可以通过术前超声来确定,我们的发现可能有助于初步诊断为PHPT的患者的术前评估。
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来源期刊
Romanian Journal of Internal Medicine
Romanian Journal of Internal Medicine MEDICINE, GENERAL & INTERNAL-
CiteScore
3.20
自引率
5.30%
发文量
35
审稿时长
15 weeks
期刊介绍: Romanian Journal of Physics is a journal publishing physics contributions on the following themes: •Theoretical Physics & Applied Mathematics •Nuclear Physics •Solid State Physics & Materials Science •Statistical Physics & Quantum Mechanics •Optics •Spectroscopy •Plasma & Lasers •Nuclear & Elementary Particles Physics •Atomic and Molecular Physics •Astrophysics •Atmosphere and Earth Science •Environment Protection
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