Prevalence of Iron Deficiency and its Association With Breast Cancer in Premenopausal Compared to Postmenopausal Women in Al Ahsa, Saudi Arabia.

IF 2.4 Q2 MATHEMATICAL & COMPUTATIONAL BIOLOGY Cancer Informatics Pub Date : 2023-01-01 DOI:10.1177/11769351231172589
Mohammad Al Khamees, Aymen A Alqurain, Abdulmonem A Alsaleh, Yousef A Alhashem, Nida AlSaffar, Noura N Alibrahim, Fardus A Aljunibi, Zaheda Alradwan, Nesreen Almohammade, Bader AlAlwan
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Abstract

Iron is an essential cofactor needed for normal functions of various enzymes and its depletion lead to increase DNA damage, genomic instability, deteriorate innate, adaptive immunity, and promote tumor development. It is also linked to tumorigenesis of breast cancer cells through enhancing mammary tumor growth and metastasis. There is insufficient data describing this association in Saudi Arabia. This study aims to determine the prevalence of iron deficiency and its association with breast cancer among premenopausal and postmenopausal women referred for breast cancer screening center in Al Ahsa, Eastern Province of Saudi Arabia. Age, hemoglobin level, iron level, history of anemia, or iron deficiency were collected from patients' medical records. The included participants were grouped based on their age into premenopausal (<50 years) or postmenopausal (⩾50 years). The definition of low Hb implemented (Hb below 12 g/dL) and low total serum Iron levels (below 8 μmol/L). Logistic regression test was used to compute the association between having a positive cancer screening test (radiological or histocytological) and participant's lab results. The results are presented as odds ratios and 95% confidence intervals. Thrree hundred fifty-seven women were included, 77% (n = 274) of them were premenopausal. This group cases had more history of iron deficiency (149 [60%] vs 25 (30%), P = .001) compared to those in the postmenopausal group. The risk of having a positive radiological cancer screening test was associated with age (OR = 1.04, 95% CI 1.02-1.06), but negatively was associated with iron level (OR = 0.9, 95% CI 0.86-0.97) among the entire cohort. This study is the first to propose an association between iron deficiency and breast cancer among Saudi young females. This could suggest iron level as a new risk factor that may be used by clinicians to assess breast cancer risk.

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在沙特阿拉伯的Al Ahsa,与绝经后妇女相比,绝经前妇女缺铁的患病率及其与乳腺癌的关系
铁是多种酶正常功能所需的重要辅助因子,其耗竭会导致DNA损伤增加,基因组不稳定,先天免疫和适应性免疫恶化,促进肿瘤发展。它还通过促进乳腺肿瘤的生长和转移与乳腺癌细胞的肿瘤发生有关。在沙特阿拉伯没有足够的数据描述这种关联。本研究旨在确定在沙特阿拉伯东部省Al Ahsa乳腺癌筛查中心转介的绝经前和绝经后妇女中缺铁的患病率及其与乳腺癌的关系。收集患者的年龄、血红蛋白水平、铁水平、贫血史或缺铁史。与绝经后组相比,纳入的参与者根据年龄分为绝经前组(P = 0.001)。在整个队列中,放射学癌症筛查试验阳性的风险与年龄相关(OR = 1.04, 95% CI 1.02-1.06),但与铁水平负相关(OR = 0.9, 95% CI 0.86-0.97)。这项研究首次提出了沙特年轻女性缺铁与乳腺癌之间的联系。这可能表明铁水平作为一个新的危险因素,可能被临床医生用来评估乳腺癌的风险。
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来源期刊
Cancer Informatics
Cancer Informatics Medicine-Oncology
CiteScore
3.00
自引率
5.00%
发文量
30
审稿时长
8 weeks
期刊介绍: The field of cancer research relies on advances in many other disciplines, including omics technology, mass spectrometry, radio imaging, computer science, and biostatistics. Cancer Informatics provides open access to peer-reviewed high-quality manuscripts reporting bioinformatics analysis of molecular genetics and/or clinical data pertaining to cancer, emphasizing the use of machine learning, artificial intelligence, statistical algorithms, advanced imaging techniques, data visualization, and high-throughput technologies. As the leading journal dedicated exclusively to the report of the use of computational methods in cancer research and practice, Cancer Informatics leverages methodological improvements in systems biology, genomics, proteomics, metabolomics, and molecular biochemistry into the fields of cancer detection, treatment, classification, risk-prediction, prevention, outcome, and modeling.
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