The effect of externally applied traditional Chinese medicine in diabetic foot: A systematic review and meta-analysis of 34 RCTs

Q2 Health Professions Foot Pub Date : 2023-09-01 DOI:10.1016/j.foot.2023.102045

Yan-Wu Yang , Yi-Wu Zhou , Mei-Ling Ge

{"title":"The effect of externally applied traditional Chinese medicine in diabetic foot: A systematic review and meta-analysis of 34 RCTs","authors":"Yan-Wu Yang , Yi-Wu Zhou , Mei-Ling Ge","doi":"10.1016/j.foot.2023.102045","DOIUrl":null,"url":null,"abstract":"<div><h3>Aim</h3><p>This study aimed to investigate the clinical efficacy of externally applied Traditional Chinese Medicine (TCM) on diabetic foot.</p></div><div><h3>Methods</h3><p>We searched the China Knowledge Network (CNKI), Wanfang Database, PubMed and Web of Science from inception to July 31, 2022, to find all randomized control trials (RCTs) related to externally applied TCMs in diabetic foot treatment. Information about the total effective rate, healing rate, and healing time were extracted. In addition, the relative risk (RR)/odds ratio (OR) or standardized mean difference (SMD) and 95 % confidence interval (CI) were calculated.</p></div><div><h3>Results</h3><p>Finally, a total of 34 RCTs including 3758 patients were included in this meta-analysis. There were 5 articles that reported hydropathic compress with astrogalin, 14 articles that reported MEBO burn cream, 9 articles that reported compound cortex phellodendri liquid and 6 articles that reported Shengji Yuhong ointment. Compared with the basic treatment, the externally applied TCM (astrogalin, MEBO burn cream, compound cortex phellodendri liquid and Shengji Yuhong ointment) combined with basic treatment improved the total effective rate (RR = 1.31 [1.20, 1.42], P < 0.0001) and healing rate (RR = 1.84 [1.56, 2.17], P < 0.0001) and shortened the healing time (SMD = − 2.51 [− 3.39, − 1.63], P < 0.0001).</p></div><div><h3>Conclusion</h3><p>Our systematic review and meta-analysis revealed that common TCM applied externally could significantly improve the clinical efficacy comparing to the basic treatment.</p></div>","PeriodicalId":12349,"journal":{"name":"Foot","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Foot","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S095825922300086X","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"Health Professions","Score":null,"Total":0}

引用次数: 0

Abstract

Aim

This study aimed to investigate the clinical efficacy of externally applied Traditional Chinese Medicine (TCM) on diabetic foot.

Methods

We searched the China Knowledge Network (CNKI), Wanfang Database, PubMed and Web of Science from inception to July 31, 2022, to find all randomized control trials (RCTs) related to externally applied TCMs in diabetic foot treatment. Information about the total effective rate, healing rate, and healing time were extracted. In addition, the relative risk (RR)/odds ratio (OR) or standardized mean difference (SMD) and 95 % confidence interval (CI) were calculated.

Results

Finally, a total of 34 RCTs including 3758 patients were included in this meta-analysis. There were 5 articles that reported hydropathic compress with astrogalin, 14 articles that reported MEBO burn cream, 9 articles that reported compound cortex phellodendri liquid and 6 articles that reported Shengji Yuhong ointment. Compared with the basic treatment, the externally applied TCM (astrogalin, MEBO burn cream, compound cortex phellodendri liquid and Shengji Yuhong ointment) combined with basic treatment improved the total effective rate (RR = 1.31 [1.20, 1.42], P < 0.0001) and healing rate (RR = 1.84 [1.56, 2.17], P < 0.0001) and shortened the healing time (SMD = − 2.51 [− 3.39, − 1.63], P < 0.0001).

Conclusion

Our systematic review and meta-analysis revealed that common TCM applied externally could significantly improve the clinical efficacy comparing to the basic treatment.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

中药外敷治疗糖尿病足的疗效：34项随机对照试验的系统回顾和荟萃分析。

目的：探讨中药外敷治疗糖尿病足的临床疗效。方法：检索中国知识网（CNKI）、万方数据库、PubMed和Web of Science自成立至2022年7月31日的所有与糖尿病足外用中药相关的随机对照试验。提取有关总有效率、愈合率和愈合时间的信息。此外，还计算了相对风险（RR）/比值比（OR）或标准化平均差（SMD）和95%置信区间（CI）。结果：本荟萃分析共纳入34项随机对照试验，包括3758名患者。有5篇文章报道了astrogalin水敷，14篇报道了MEBO烧伤膏，9篇报道了复方黄柏液，6篇报道了生脊愈红膏。与基础治疗相比，外用中药（黄芪甲素、MEBO烧伤膏、复方黄柏液、生脊愈红膏）配合基础治疗，总有效率提高（RR=1.31[1.20，1.42]，P）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Foot Health Professions-Podiatry

CiteScore

2.00

自引率

0.00%

发文量

期刊介绍： The Foot is an international peer-reviewed journal covering all aspects of scientific approaches and medical and surgical treatment of the foot. The Foot aims to provide a multidisciplinary platform for all specialties involved in treating disorders of the foot. At present it is the only journal which provides this inter-disciplinary opportunity. Primary research papers cover a wide range of disorders of the foot and their treatment, including diabetes, vascular disease, neurological, dermatological and infectious conditions, sports injuries, biomechanics, bioengineering, orthoses and prostheses.