Metformin ameliorates cardiopulmonary toxicity induced by chlorpyrifos.

IF 2.1 4区医学 Q3 CHEMISTRY, MULTIDISCIPLINARY Drug and Chemical Toxicology Pub Date : 2024-09-01 Epub Date: 2023-07-28 DOI:10.1080/01480545.2023.2239523

Ramtin Farhadi, Marzieh Daniali, Maryam Baeeri, Roham Foroumadi, Mahdi Gholami, Shokoufeh Hassani, Soheyl Mirzababaei, Hamed Haghi-Aminjan, Mona Navaei-Nigjeh, Mahban Rahimifard, Mohammad Abdollahi

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Abstract

Chlorpyrifos (CPF) is a widely used pesticide that can impair body organs. Nonetheless, metformin is known for its protective role against dysfunction at cellular and molecular levels led by inflammatory and oxidative stress. This study aimed to investigate the modulatory impacts of metformin on CPF-induced heart and lung damage. Following the treatment of Wistar rats with different combinations of metformin and CPF, plasma, as well as heart and lung tissues, were isolated to examine the level of oxidative stress biomarkers like reactive oxygen species (ROS) and malondialdehyde (MDA), inflammatory cytokines such as tumor necrosis alpha (TNF-α), high mobility group box 1 (HMGB1) gene, deoxyribonucleic acid (DNA) damage, lactate, ADP/ATP ratio, expression of relevant genes (TRADD, TERT, KL), and along with histological analysis. Based on the findings, metformin significantly modulates the impairments in heart and lung tissues induced by CPF.

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二甲双胍可改善毒死蜱引起的心肺毒性。

毒死蜱（CPF）是一种广泛使用的杀虫剂，会损害人体器官。然而，二甲双胍对炎症和氧化应激导致的细胞和分子水平的功能障碍具有保护作用。本研究旨在探讨二甲双胍对氯化石蜡诱发的心肺损伤的调节作用。用二甲双胍和氯化石蜡的不同组合处理 Wistar 大鼠后，分离血浆以及心肺组织，以检测氧化应激生物标志物（如活性氧（ROS）和丙二醛（MDA））的水平、炎症细胞因子，如肿瘤坏死α（TNF-α）、高迁移率组盒 1（HMGB1）基因、脱氧核糖核酸（DNA）损伤、乳酸、ADP/ATP 比率、相关基因（TRADD、TERT、KL）的表达，以及组织学分析。研究结果表明，二甲双胍能明显减轻 CPF 对心肺组织的损伤。

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来源期刊

Drug and Chemical Toxicology 医学-毒理学

CiteScore

6.00

自引率

3.80%

发文量

审稿时长

3 months

期刊介绍： Drug and Chemical Toxicology publishes full-length research papers, review articles and short communications that encompass a broad spectrum of toxicological data surrounding risk assessment and harmful exposure. Manuscripts are considered according to their relevance to the journal. Topics include both descriptive and mechanics research that illustrates the risk assessment implications of exposure to toxic agents. Examples of suitable topics include toxicological studies, which are structural examinations on the effects of dose, metabolism, and statistical or mechanism-based approaches to risk assessment. New findings and methods, along with safety evaluations, are also acceptable. Special issues may be reserved to publish symposium summaries, reviews in toxicology, and overviews of the practical interpretation and application of toxicological data.