Starvation-inactivated MTOR triggers cell migration via a ULK1-SH3PXD2A/TKS5-MMP14 pathway in ovarian carcinoma.

IF 14.6 1区生物学 Q1 CELL BIOLOGY Autophagy Pub Date : 2023-12-01 Epub Date: 2023-07-28 DOI:10.1080/15548627.2023.2239633

Chiao-Yun Lin, Kai-Yun Wu, Lang-Ming Chi, Yun-Hsin Tang, Huei-Jean Huang, Chyong-Huey Lai, Chi-Neu Tsai, Chia-Lung Tsai

引用次数: 0

Abstract

Abbreviations: AMPK: AMP-activated protein kinase; CHX: cycloheximide; RAD001: everolimus; HBSS: Hanks' balanced salt solution; LC-MS/MS: liquid chromatography-mass spectrometry/mass spectrometry; MMP14: matrix metallopeptidase 14; MTOR: mechanistic target of rapamycin kinase; MAPK: mitogen-activated protein kinase; RB1CC1/FIP200: RB1 inducible coiled-coil 1; PtdIns3P: phosphatidylinositol-3-phosphate; PX: phox homology; SH3: Src homology 3; SH3PXD2A/TKS5: SH3 and PX domains 2A; SH3PXD2A-[6A]: S112A S142A S146A S147A S175A S348A mutant; ULK1: unc-51 like autophagy activating kinase 1.

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在卵巢癌中，饥饿灭活的MTOR通过ULK1-SH3PXD2A/TKS5-MMP14途径触发细胞迁移。

缩写：AMPK：AMP活化蛋白激酶；CHX：环己酰亚胺；RAD001：依维莫司；HBSS：汉克斯平衡盐溶液；LC-MS/MS：液相色谱-质谱法/质谱法；MMP14：基质金属肽酶14；MTOR：雷帕霉素激酶的机制靶点；MAPK：丝裂原活化蛋白激酶；RB1CC1/FIP200:RB1诱导型线圈1；PtdIns3P：磷脂酰肌醇-3-磷酸；PX：phox同源性；SH3:Src同源性3；SH3PXD2A/TKS5:SH3和PX结构域2A；SH3PXD2A-[6A]:S112A S142A S146A S147A S175A S348A突变体；ULK1:unc-51样自噬激活激酶1。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Autophagy 生物-细胞生物学

CiteScore

21.30

自引率

2.30%

发文量

277

审稿时长

1 months

期刊介绍： Autophagy is a peer-reviewed journal that publishes research on autophagic processes, including the lysosome/vacuole dependent degradation of intracellular material. It aims to be the premier journal in the field and covers various connections between autophagy and human health and disease, such as cancer, neurodegeneration, aging, diabetes, myopathies, and heart disease. Autophagy is interested in all experimental systems, from yeast to human. Suggestions for specialized topics are welcome. The journal accepts the following types of articles: Original research, Reviews, Technical papers, Brief Reports, Addenda, Letters to the Editor, Commentaries and Views, and Articles on science and art. Autophagy is abstracted/indexed in Adis International Ltd (Reactions Weekly), EBSCOhost (Biological Abstracts), Elsevier BV (EMBASE and Scopus), PubMed, Biological Abstracts, Science Citation Index Expanded, Web of Science, and MEDLINE.