Plasmapheresis can correct refractoriness of insulin on triglyceride metabolism - A case report of hypertriglyceridemia-induced acute pancreatitis.

IF 0.8 Q3 MEDICINE, GENERAL & INTERNAL Archive of clinical cases Pub Date : 2023-01-01 DOI:10.22551/2023.39.1002.10244
Bala Sundaram, Nabadwip Pathak, Sunil Kumar Nanda
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Abstract

Hypertriglyceridemia associated acute pancreatitis is a medical emergency and it causes significant morbidity and mortality. Here we report a case of 47 years old male with hypertriglyceridemia associated acute pancreatitis. The diagnosis was confirmed by elevated serum triglyceride levels and elevated lipase levels. Initially, Insulin infusion started with fibrates and statins but due to worsening hypertriglyceridemia and he underwent one session of plasmapheresis, following which triglyceride levels improved. Triglyceride assessment in removed plasma in plasmapheresis showed that the amount of triglyceride level reduction was 4 times the amount removed in plasmapheresis. The study showed that plasmapheresis improves insulin-related triglyceride metabolism besides removal.

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血浆置换可纠正胰岛素对甘油三酯代谢的难治性——高甘油三酯血症致急性胰腺炎1例报告。
高甘油三酯血症相关的急性胰腺炎是一种医学紧急情况,它会导致显著的发病率和死亡率。我们在此报告一例47岁男性高甘油三酯血症相关急性胰腺炎。血清甘油三酯水平升高和脂肪酶水平升高证实了诊断。最初,胰岛素输注开始使用贝特酸盐和他汀类药物,但由于高甘油三酯血症恶化,他进行了一次血浆置换,随后甘油三酯水平改善。血浆置换去除血浆中甘油三酯的评估显示,甘油三酯水平降低的量是血浆置换去除量的4倍。该研究表明,血浆置换除了去除胰岛素外,还能改善与胰岛素相关的甘油三酯代谢。
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