BAG2 Is a Novel Prognostic Biomarker and Promising Immunotherapy Target in Uveal Melanoma.

IF 1.5 4区 医学 Q4 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Critical Reviews in Eukaryotic Gene Expression Pub Date : 2023-01-01 DOI:10.1615/CritRevEukaryotGeneExpr.2023048565
Chaolin Li, Hao Shi
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Abstract

Background: The importance of BAG2 in malignancy is gradually being recognized, however, information on its role in uveal melanoma (UVM) is limited. We aimed to elucidate its function and potential mechanism of action in UVM.

Methods: Using the Cancer Genome Atlas (TCGA) and GEO-related datasets, we analyzed the differential expression of BAG2 in tumors, combined with clinical information and methylation data to analyze the prognostic value of BAG2, differential methylation and its association with UVM metastasis. In addition, correlation analysis explored the immunological characteristics of BAG2 in UVM and the response to immunotherapy. Finally, a prognostic model of ferroptosis- related genes was constructed and validated.

Results: BAG2 is significantly downregulated in multiple cancers including UVM. Prognostic analysis showed that BAG2 was an independent prognostic factor for UVM. Abnormal methylation of BAG2 may affect the metastasis of UVM and be significantly associated with poor prognosis. Immune analysis clarified that BAG2 was significantly associated with UVM immune cell infiltration and multiple immune checkpoints, and low expression of BAG2 was more beneficial in immunotherapy. In addition, the prognostic model of ferroptosis we constructed has good performance in predicting overall survival and metastasis-free survival of UVM.

Conclusions: BAG2 is an independent prognostic factor for UVM and may be a potential immune checkpoint for UVM.

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BAG2是一种新的预后生物标志物和有希望的葡萄膜黑色素瘤免疫治疗靶点。
背景:BAG2在恶性肿瘤中的重要性正逐渐被认识到,然而,关于其在葡萄膜黑色素瘤(UVM)中的作用的信息有限。我们旨在阐明其在UVM中的作用及其潜在机制。方法:利用肿瘤基因组图谱(Cancer Genome Atlas, TCGA)和geo相关数据集,分析BAG2在肿瘤中的差异表达,结合临床信息和甲基化数据,分析BAG2的预后价值、差异甲基化及其与UVM转移的关系。此外,通过相关分析探讨了BAG2在UVM中的免疫学特性及其对免疫治疗的反应。最后,构建并验证了铁下垂相关基因的预后模型。结果:BAG2在包括UVM在内的多种癌症中显著下调。预后分析显示BAG2是UVM的独立预后因素。BAG2异常甲基化可能影响UVM的转移,并与不良预后显著相关。免疫分析表明BAG2与UVM免疫细胞浸润和多个免疫检查点显著相关,低表达BAG2在免疫治疗中更有利。此外,我们构建的铁下垂预后模型在预测UVM的总生存期和无转移生存期方面具有良好的性能。结论:BAG2是UVM的独立预后因素,可能是UVM的潜在免疫检查点。
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来源期刊
Critical Reviews in Eukaryotic Gene Expression
Critical Reviews in Eukaryotic Gene Expression 生物-生物工程与应用微生物
CiteScore
2.70
自引率
0.00%
发文量
67
审稿时长
1 months
期刊介绍: Critical ReviewsTM in Eukaryotic Gene Expression presents timely concepts and experimental approaches that are contributing to rapid advances in our mechanistic understanding of gene regulation, organization, and structure within the contexts of biological control and the diagnosis/treatment of disease. The journal provides in-depth critical reviews, on well-defined topics of immediate interest, written by recognized specialists in the field. Extensive literature citations provide a comprehensive information resource. Reviews are developed from an historical perspective and suggest directions that can be anticipated. Strengths as well as limitations of methodologies and experimental strategies are considered.
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