Biomaterials-Mediated Engineering of the Immune System.

IF 26.9 1区 医学 Q1 IMMUNOLOGY Annual review of immunology Pub Date : 2023-04-26 DOI:10.1146/annurev-immunol-101721-040259
Coralie Backlund, Sasan Jalili-Firoozinezhad, Byungji Kim, Darrell J Irvine
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引用次数: 3

Abstract

Modulation of the immune system is an important therapeutic strategy in a wide range of diseases, and is fundamental to the development of vaccines. However, optimally safe and effective immunotherapy requires precision in the delivery of stimulatory cues to the right cells at the right place and time, to avoid toxic overstimulation in healthy tissues or incorrect programming of the immune response. To this end, biomaterials are being developed to control the location, dose, and timing of vaccines and immunotherapies. Here we discuss fundamental concepts of how biomaterials are used to enhance immune modulation, and evidence from preclinical and clinical studies of how biomaterials-mediated immune engineering can impact the development of new therapeutics. We focus on immunological mechanisms of action and in vivo modulation of the immune system, and we also discuss challenges to be overcome to speed translation of these technologies to the clinic.

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生物材料介导的免疫系统工程。
免疫系统的调节是多种疾病的重要治疗策略,也是疫苗开发的基础。然而,最安全有效的免疫疗法需要在正确的地点和时间精确地将刺激信号传递给正确的细胞,以避免健康组织中的毒性过度刺激或免疫反应的错误编程。为此目的,正在开发生物材料,以控制疫苗和免疫疗法的地点、剂量和时间。在这里,我们讨论了生物材料如何用于增强免疫调节的基本概念,以及生物材料介导的免疫工程如何影响新疗法发展的临床前和临床研究的证据。我们专注于免疫作用机制和免疫系统的体内调节,我们也讨论了需要克服的挑战,以加快这些技术到临床的翻译。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Annual review of immunology
Annual review of immunology 医学-免疫学
CiteScore
57.20
自引率
0.70%
发文量
29
期刊介绍: The Annual Review of Immunology, in publication since 1983, focuses on basic immune mechanisms and molecular basis of immune diseases in humans. Topics include innate and adaptive immunity; immune cell development and differentiation; immune control of pathogens (viruses, bacteria, parasites) and cancer; and human immunodeficiency and autoimmune diseases. The current volume of this journal has been converted from gated to open access through Annual Reviews' Subscribe to Open program, with all articles published under a CC BY license.
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