Connexin-Based Channels in the Liver.

IF 4.2 2区 医学 Q1 PHYSIOLOGY Comprehensive Physiology Pub Date : 2022-08-11 DOI:10.1002/cphy.c220007
Raf Van Campenhout, Kaat Leroy, Axelle Cooreman, Andrés Tabernilla, Bruno Cogliati, Prashant Kadam, Mathieu Vinken
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引用次数: 1

Abstract

Connexin proteins oligomerize in hexameric structures called connexin hemichannels, which then dock to form gap junctions. Gap junctions direct cell-cell communication by allowing the exchange of small molecules and ions between neighboring cells. In this way, hepatic gap junctions support liver homeostasis. Besides serving as building blocks for gap junctions, connexin hemichannels provide a pathway between the intracellular and the extracellular environment. The activation of connexin hemichannels is associated with acute and chronic liver pathologies. This article discusses the role of gap junctions and connexin hemichannels in the liver. © 2022 American Physiological Society. Compr Physiol 12:1-17, 2022.

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肝脏中基于连接蛋白的通道。
连接蛋白寡聚成六聚体结构,称为连接蛋白半通道,然后停靠形成间隙连接。间隙连接通过允许相邻细胞之间的小分子和离子交换来指导细胞间的通讯。通过这种方式,肝间隙连接支持肝脏稳态。除了作为缝隙连接的基石外,连接蛋白半通道还提供了细胞内和细胞外环境之间的途径。连接蛋白半通道的激活与急性和慢性肝脏病变有关。本文讨论了间隙连接和连接蛋白半通道在肝脏中的作用。©2022美国生理学会。物理学报(英文版),2012。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
10.50
自引率
0.00%
发文量
38
审稿时长
6-12 weeks
期刊介绍: Comprehensive Physiology is the most authoritative and comprehensive collection of physiology information ever assembled, and uses the most powerful features of review journals and electronic reference works to cover the latest key developments in the field, through the most authoritative articles on the subjects covered. This makes Comprehensive Physiology a valued reference work on the evolving science of physiology for both researchers and clinicians. It also provides a useful teaching tool for instructors and an informative resource for medical students and other students in the life and health sciences.
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