Connexin-Based Channels in the Liver.
Raf Van Campenhout, Kaat Leroy, Axelle Cooreman, Andrés Tabernilla, Bruno Cogliati, Prashant Kadam, Mathieu Vinken
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Abstract
Connexin proteins oligomerize in hexameric structures called connexin hemichannels, which then dock to form gap junctions. Gap junctions direct cell-cell communication by allowing the exchange of small molecules and ions between neighboring cells. In this way, hepatic gap junctions support liver homeostasis. Besides serving as building blocks for gap junctions, connexin hemichannels provide a pathway between the intracellular and the extracellular environment. The activation of connexin hemichannels is associated with acute and chronic liver pathologies. This article discusses the role of gap junctions and connexin hemichannels in the liver. © 2022 American Physiological Society. Compr Physiol 12:1-17, 2022.
肝脏中基于连接蛋白的通道。
连接蛋白寡聚成六聚体结构，称为连接蛋白半通道，然后停靠形成间隙连接。间隙连接通过允许相邻细胞之间的小分子和离子交换来指导细胞间的通讯。通过这种方式，肝间隙连接支持肝脏稳态。除了作为缝隙连接的基石外，连接蛋白半通道还提供了细胞内和细胞外环境之间的途径。连接蛋白半通道的激活与急性和慢性肝脏病变有关。本文讨论了间隙连接和连接蛋白半通道在肝脏中的作用。©2022美国生理学会。物理学报(英文版)，2012。
本文章由计算机程序翻译，如有差异，请以英文原文为准。
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