Association of Changes in Thickness of Limbal Epithelial and Stroma with Corneal Scars Detected by High-Resolution Anterior Segment Optic Coherence Tomography.

IF 0.8 4区医学 Q4 OPHTHALMOLOGY Klinische Monatsblatter fur Augenheilkunde Pub Date : 2024-06-01 Epub Date: 2022-05-03 DOI:10.1055/a-1842-2683

Hande Guclu, Samira Sattarpanah, Vuslat Gurlu

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Abstract

Aim: To investigate the corneal central and limbal thickness in cornea scar patients using high-resolution anterior segment optical coherence tomography (AS-OCT) and to determine the changes in the limbal region due to the corneal scar. Also, to evaluate tear film parameters in scar patients.

Methods: Thirty patients with central corneal scar and 30 control subjects. The control subjects were healthy individuals who came to our clinic for routine ophthalmological examination. They were enrolled in this matched case-control study. Central epithelial thickness (ET), stromal thickness (ST), limbal epithelial thickness (LET), and limbal stromal thickness (LST) were analyzed using high-resolution AS-OCT. For evaluation of the ocular surface, the following techniques were used: tear break-up time (BUT) employing standard sterile strips of fluorescein sodium, Schirmer test-I (SCH), and the Ocular Surface Disease Index (OSDI) Questionnaire.

Results: The mean central ET of the patient group was 51.5 ± 12.4 µm, while the mean central ET of the control group was 59.2 ± 9.0 µm. There was a statistically significant difference between patients and controls (p = 0.008). The mean LST of the patients was 747.9 ± 115.7 µm, and the mean LST of the controls was 726.3 ± 79.7 µm. There was a statistically significant difference between patients and controls according to BUT (p = 0.009) and SCH (p = 0.04). However, there was no significant difference between OSDI results of patients and controls (p = 0.08).

Conclusion: Corneal monitoring with high-resolution AS-OCT is a simple, noninvasive, useful technique for corneal scar patients. Cornea scars cause decreased ET. This result could be associated with lower tear film parameters in scar patients. The scar length is associated with higher intraocular pressure (IOP) values. Decreased LET and increased LST were detected in scar patients.

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角膜缘上皮和基质厚度的变化与高分辨率前段光学相干断层扫描检测到的角膜瘢痕的关联。

目的：使用高分辨率眼前节光学相干断层扫描（AS-OCT）研究角膜瘢痕患者的角膜中央和角膜缘厚度，并确定角膜瘢痕导致的角膜缘区域的变化。此外，还评估瘢痕患者的泪膜参数：方法：30 名中央角膜瘢痕患者和 30 名对照组受试者。方法：30 名中央型角膜瘢痕患者和 30 名对照组受试者，对照组受试者为前来本诊所进行常规眼科检查的健康人。他们被纳入这项匹配病例对照研究。研究人员使用高分辨率 AS-OCT 分析了中央上皮厚度 (ET)、基质厚度 (ST)、角膜缘上皮厚度 (LET) 和角膜缘基质厚度 (LST)。眼表评估采用了以下技术：使用标准荧光素钠无菌条的泪液破裂时间（BUT）、Schirmer 测试-I（SCH）和眼表疾病指数（OSDI）问卷：患者组的中心 ET 平均值为 51.5 ± 12.4 µm，而对照组的中心 ET 平均值为 59.2 ± 9.0 µm。患者和对照组之间的差异具有统计学意义（P = 0.008）。患者的平均 LST 为 747.9 ± 115.7 µm，对照组的平均 LST 为 726.3 ± 79.7 µm。患者和对照组在 BUT（p = 0.009）和 SCH（p = 0.04）方面存在显著统计学差异。然而，患者和对照组的OSDI结果没有明显差异（p = 0.08）：结论：使用高分辨率 AS-OCT 进行角膜监测是一项简单、无创、对角膜疤痕患者有用的技术。角膜疤痕会导致 ET 下降。这一结果可能与疤痕患者泪膜参数较低有关。疤痕长度与眼内压（IOP）值升高有关。疤痕患者的 LET 值降低，LST 值升高。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Klinische Monatsblatter fur Augenheilkunde 医学-眼科学

CiteScore

1.30

自引率

0.00%

发文量

235

审稿时长

4-8 weeks

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