Symptom palliation with QUAD Shot radiation therapy to penile metastasis derived from descending colon cancer: a case report.

IF 0.5 Q4 ONCOLOGY International Cancer Conference Journal Pub Date : 2023-03-30 eCollection Date: 2023-07-01 DOI:10.1007/s13691-023-00604-y
Akira Yamamoto, Hideharu Ieki, Mai Shimamura, Masahiro Tsujiura, Takeshi Yokoe, Naoko Sanuki, Eiki Ojima, Keiichi Uchida, Yasuhiko Mohri
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Abstract

A 54-year-old man was diagnosed with descending colon cancer with metastases in the liver, para-aortic lymph nodes, and penis, and chemotherapy was introduced after construction of a colostomy. The patient reported only mild penile pain at the time of diagnosis; however, the pain gradually worsened and interfered with his daily life. Opioids did not provide sufficient analgesia, and the patient developed dysuria and priapism. Through construction of a cystostomy, palliative radiotherapy with QUAD Shot regimen (14 Gy in 4 fractions twice-daily on 2 days repeated every 4 weeks) to the penile metastasis was started for pain relief and tumor shrinkage. The radiation rapidly improved the penile symptoms, enabling opioid reduction and cystostomy removal. The patient remained pain-free and able to urinate on his own until his death. Metastatic penile tumors are rare, especially those derived from colon cancer. Penile metastases occur mainly in the late stages of cancer and may impair the patient's quality of life. In such cases, palliative radiotherapy, especially with QUAD Shot regimen, is useful with short treatment time, durable symptom control, and little adverse effect, maintaining quality of life.

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QUAD Shot放射治疗癌症下行期阴茎转移的症状缓解:一例报告。
一名54岁的男子被诊断为降结肠癌症,肝脏、皮质旁淋巴结和阴茎有转移,在造结肠后进行了化疗。患者在诊断时仅报告轻微的阴茎疼痛;然而,疼痛逐渐加重,影响了他的日常生活。阿片类药物不能提供足够的镇痛作用,患者出现排尿困难和阴茎异常勃起。通过建造膀胱造瘘术,开始对阴茎转移进行QUAD Shot方案的姑息性放射治疗(14 Gy,4次,每天两次,每4周重复2天),以缓解疼痛和缩小肿瘤。辐射迅速改善了阴茎症状,使阿片类药物减少和膀胱造口术得以切除。病人一直没有疼痛,可以自己小便,直到去世。转移性阴茎肿瘤是罕见的,特别是那些来源于结肠癌癌症。阴茎转移主要发生在癌症晚期,可能损害患者的生活质量。在这种情况下,姑息性放射治疗,特别是QUAD Shot方案,治疗时间短,症状控制持久,不良反应小,可保持生活质量。
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来源期刊
自引率
14.30%
发文量
57
期刊介绍: This online-only journal publishes original case reports on all types of cancer. In particular, we welcome not only case reports of educational value in the diagnosis and treatment of cancers, but also reports on molecularly analyzed cancer cases, including gene mutations, gene fusions, gene expression, and changes in copy number, regardless of their known clinical significance. Assessing the molecular analysis of a tumor usually requires a “cancer conference” in which experts from various fields discuss it. Even if the authors and their respective “cancer conference” were unable to determine the clinical significance of molecular changes at the time of submission and publication, their data may provide evidence that will help the scientific community develop precision medicine solutions in the future. We welcome case reports with reviews of the literature on similar cases, as they are more useful and valuable to readers than are reports of rare cases. International Cancer Conference Journal is the official publication of the Japan Society of Clinical Oncology (JSCO). - Presents an online-only collection of original case reports on all types of cancer - In particular, welcomes molecularly analyzed cancer cases - The Official Publication of the Japan Society of Clinical Oncology (JSCO)
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