SARS-CoV-2 infection and its effects on the endocrine system

IF 6.1 1区医学 Q1 ENDOCRINOLOGY & METABOLISM Best practice & research. Clinical endocrinology & metabolism Pub Date : 2023-07-01 DOI:10.1016/j.beem.2023.101761

Charlotte Steenblock (Principal Investigator in Endocrinology) , Nicole Toepfner (Senior Clinical Scientist in Paediatric Infectious Diseases) , Felix Beuschlein (Professor in Endocrinology and Head of Department) , Nikolaos Perakakis (Professor of Metabolic and Vascular Medicine) , Ranjit Mohan Anjana (Vice President & Managing Director) , Viswanathan Mohan (Director & Chief of Diabetes Research) , Nitish R. Mahapatra (Professor) , Stefan R. Bornstein (Professor & Clinic Director)

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引用次数: 4

Abstract

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causing corona virus disease 2019 (COVID-19) can infect multiple tissues, including endocrine organs, such as the pancreas, adrenal, thyroid, and adipose tissue. The main receptor for SARS-CoV-2, ACE2, is ubiquitously expressed in the cells of the endocrine organs and accordingly, the virus has been detected in various amounts in all endocrine tissues in post-mortem samples from COVID-19 patients. The infection with SARS-CoV-2 may directly lead to organ damage or dysfunction, such as hyperglycaemia or in rare cases, new-onset diabetes. Furthermore, an infection with SARS-CoV-2 may have indirect effects affecting the endocrine system. The exact mechanisms are not yet completely understood and have to be further investigated. Conversely, endocrine diseases may affect the severity of COVID-19 and emphasis has to be laid on reducing the prevalence, or enhance the treatment, of these often non-communicable diseases in the future.

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严重急性呼吸系统综合征冠状病毒2型感染及其对内分泌系统的影响。

导致2019冠状病毒病（新冠肺炎）的严重急性呼吸综合征冠状病毒2型（SARS-CoV-2）可感染多种组织，包括胰腺、肾上腺、甲状腺和脂肪组织等内分泌器官。SARS-CoV-2的主要受体ACE2在内分泌器官细胞中普遍表达，因此，在新冠肺炎患者的死后样本中，已在所有内分泌组织中检测到不同数量的病毒。感染严重急性呼吸系统综合征冠状病毒2型可能直接导致器官损伤或功能障碍，如高血糖，或在极少数情况下导致新发糖尿病。此外，严重急性呼吸系统综合征冠状病毒2型的感染可能对内分泌系统产生间接影响。确切的机制尚不完全清楚，必须进一步研究。相反，内分泌疾病可能会影响新冠肺炎的严重程度，未来必须重点降低这些通常不可传播疾病的流行率或加强治疗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Best practice & research. Clinical endocrinology & metabolism 医学-内分泌学与代谢

CiteScore

11.90

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Best Practice & Research Clinical Endocrinology & Metabolism is a serial publication that integrates the latest original research findings into evidence-based review articles. These articles aim to address key clinical issues related to diagnosis, treatment, and patient management. Each issue adopts a problem-oriented approach, focusing on key questions and clearly outlining what is known while identifying areas for future research. Practical management strategies are described to facilitate application to individual patients. The series targets physicians in practice or training.