Neurostimulation for Spinal Lesions: Enhancing Recovery and Axonal Regeneration.

Journal of medical research and surgery Pub Date : 2023-06-01 Epub Date: 2023-06-03 DOI:10.52916/jmrs234107
Drashti Patel, Jonathan Benjamin, Aashay Patel, Chance Fleeting, Jed Casauay, Marco Foreman, Sohum Sheth, Brandon Lucke-Wold
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Abstract

Spinal neurostimulation is a promising approach for treating spinal lesions and has implications in various neurological disorders. It promotes axonal regeneration and neuronal plasticity to reestablish disrupted signal transduction pathways following spinal injuries or degeneration. This paper reviews the current technology and its differing utilities in various types of neurostimulation, including invasive and noninvasive methods. The paper also explores the efficacy of spinal compression and decompression therapy, with a primary focus on degenerative spinal disorders. Moreover, the potential of spinal neurostimulation in therapies for motor disorders, such as Parkinson's disease and demyelinating disorders, is discussed. Finally, the paper examines the changing guidelines of use for spinal neurostimulation following surgical tumor resection. The review suggests that spinal neurostimulation is a promising therapy for axonal regeneration in spinal lesions. This paper concludes that future research should focus on the long-term effects and safety of these existing technologies, optimizing the use of spinal neurostimulation to enhance recovery and exploring its potential for other neurological disorders.

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脊髓损伤的神经刺激:加强康复和轴突再生。
脊髓神经刺激是一种治疗脊髓病变的有前途的方法,对各种神经系统疾病具有重要意义。它能促进轴突再生和神经元可塑性,重建脊柱损伤或变性后中断的信号转导通路。本文回顾了当前的技术及其在各类神经刺激中的不同效用,包括侵入性和非侵入性方法。本文还探讨了脊柱加压和减压疗法的疗效,重点关注脊柱退行性疾病。此外,本文还讨论了脊髓神经刺激在帕金森病和脱髓鞘疾病等运动障碍治疗中的潜力。最后,本文探讨了肿瘤手术切除后脊髓神经刺激使用指南的变化。综述表明,脊髓神经刺激是脊髓病变轴突再生的一种有前途的疗法。本文的结论是,未来的研究应关注这些现有技术的长期效果和安全性,优化脊髓神经刺激的使用以促进康复,并探索其用于其他神经系统疾病的潜力。
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