Nomenclature for factors of the HLA system, update April, May and June 2023

Abstract

The following sequences have been submitted to the Nomenclature Committee since the January, February and March 2023 nomenclature update (Marsh, 2023) and, following agreed policy, have been assigned official allele designations (Marsh et al., 2010). Full details of all sequences will be published in a forthcoming report. Below are listed the newly assigned sequences (Table 1) and confirmations of previously reported sequences (Table 2). The accession number of each sequence is given and these can be used to retrieve the sequence files from the EMBL, GenBank or DDBJ data libraries. Although accession numbers have been assigned by the data libraries and most sequences are already available, there is still the possibility that an author may not yet have allowed the sequence to be released; in such a case, you will have to contact the submitting author directly. Additional information pertaining to new sequences is often included in the publications describing these alleles; a listing of recent publications that describe new HLA sequences is given in Table 3. An additional 122 alleles were recently published but have not been included in Table 3 due to space considerations (Bishara et al., 2023). In addition, the alleles A*02:03:12, A*03:01:96, A*11:01:98, A*30:02:25, A*34:01:06, A*68:01:59, DRB1*10:38Q and DRB1*11:01:01:12Q have had suffix changes and have been renamed A*02:03:12Q, A*03:01:96Q, A*11:01:98Q, A*30:02:25Q, A*34:01:06Q, A*68:01:59Q, DRB1*10:38 and DRB1*11:01:01:12N, respectively. Furthermore, the sequence for the allele A*24:459:02 was named in error and has been renamed A*24:608. The name A*24:459:02 has therefore been deleted. Finally, the allele B*56:05:02 was extended and renamed B*56:94. The allele name B*56:05:02 has been deleted. All new and confirmatory sequences should now be submitted directly to theWHONomenclature Committee for Factors of the HLA System via the IPD-IMGT/HLA Database using the sequence submission tool provided (Barker et al., 2023). The IPD-IMGT/HLA Database may be accessed via the World WideWeb at www.ebi.ac.uk/ipd/imgt/ hla.