The therapygenetics of anxiety disorders.

IF 1.5 4区医学 Q4 GENETICS & HEREDITY Psychiatric Genetics Pub Date : 2023-08-01 DOI:10.1097/YPG.0000000000000342

Srishti Vashishtha, Stefan Kloiber, Gwyneth Zai

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Abstract

Treatment of anxiety disorders primarily includes pharmacological treatment and psychotherapy, yet a substantial portion of patients do not experience sufficient clinical response. Given the significant impact of anxiety disorders on well-being and quality of life, it is pertinent to strive to ensure available treatments are of paramount efficacy. This review aimed to identify genetic variants and genes that may moderate the outcome of psychotherapy in patients with anxiety disorders, termed 'therapygenetics.' A comprehensive search of the current literature following relevant guidelines was conducted. Eighteen records were included in the review. Seven studies reported significant associations between genetic variants and response to psychotherapy. The most investigated polymorphisms were the serotonin transporter-linked polymorphic region (5-HTTLPR), nerve growth factor rs6330, catechol-O-methyltransferase Val158Met, and brain-derived neurotrophic factor Val166Met. However, current findings are inconsistent and thus do not support the use of genetic variants for the prediction of psychotherapy response in anxiety disorders.

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焦虑症的治疗遗传学。

焦虑障碍的治疗主要包括药物治疗和心理治疗，但相当一部分患者没有充分的临床反应。鉴于焦虑症对幸福感和生活质量的重大影响，努力确保现有治疗方法具有最高功效是相关的。这篇综述的目的是确定可能调节焦虑障碍患者心理治疗结果的遗传变异和基因，称为“治疗遗传学”。根据相关指南对当前文献进行了全面的检索。18项记录被纳入审查。七项研究报告了基因变异与心理治疗反应之间的显著关联。研究最多的多态性是5-羟色胺转运体相关多态性区(5-HTTLPR)、神经生长因子rs6330、儿茶酚- o -甲基转移酶Val158Met和脑源性神经营养因子Val166Met。然而，目前的研究结果是不一致的，因此不支持使用遗传变异来预测焦虑症的心理治疗反应。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Psychiatric Genetics 医学-神经科学

CiteScore

2.30

自引率

0.00%

发文量

审稿时长

3 months

期刊介绍： The journal aims to publish papers which bring together clinical observations, psychological and behavioural abnormalities and genetic data. All papers are fully refereed. Psychiatric Genetics is also a forum for reporting new approaches to genetic research in psychiatry and neurology utilizing novel techniques or methodologies. Psychiatric Genetics publishes original Research Reports dealing with inherited factors involved in psychiatric and neurological disorders. This encompasses gene localization and chromosome markers, changes in neuronal gene expression related to psychiatric disease, linkage genetics analyses, family, twin and adoption studies, and genetically based animal models of neuropsychiatric disease. The journal covers areas such as molecular neurobiology and molecular genetics relevant to mental illness. Reviews of the literature and Commentaries in areas of current interest will be considered for publication. Reviews and Commentaries in areas outside psychiatric genetics, but of interest and importance to Psychiatric Genetics, will also be considered. Psychiatric Genetics also publishes Book Reviews, Brief Reports and Conference Reports.