{"title":"Nasopharyngeal carcinoma. A \"different\" head and neck tumour. Part B: treatment, prognostic factors, and outcomes.","authors":"Giulio Cantù","doi":"10.14639/0392-100X-N2223","DOIUrl":null,"url":null,"abstract":"SUMMARY Nasopharyngeal carcinoma (NPC) is the most interesting and intriguing malignant tumour located in the nasopharynx, because it is a “peculiar” malignancy, “different” from almost all the other head and neck tumours according to several points of view. Given that radiotherapy (RT) is the treatment of choice for NPC, chemotherapy (CT) has been added to standard RT to improve outcome in high-risk patients, either as an adjuvant, neoadjuvant or concurrent treatment modality with radiation. Surgery plays an important role in rescuing recurrent or persistent disease after primary (CT)RT. This second part of the review provides a critical analysis of various treatment described in the literature, both for primary cancer and for regional and distant metastases. The prognostic factors and the final results of the various treatments will also be analysed.","PeriodicalId":6890,"journal":{"name":"Acta Otorhinolaryngologica Italica","volume":"43 3","pages":"155-169"},"PeriodicalIF":2.1000,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/5b/ef/aoi-2023-03-155.PMC10198365.pdf","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Acta Otorhinolaryngologica Italica","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.14639/0392-100X-N2223","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"OTORHINOLARYNGOLOGY","Score":null,"Total":0}
引用次数: 1
Abstract
SUMMARY Nasopharyngeal carcinoma (NPC) is the most interesting and intriguing malignant tumour located in the nasopharynx, because it is a “peculiar” malignancy, “different” from almost all the other head and neck tumours according to several points of view. Given that radiotherapy (RT) is the treatment of choice for NPC, chemotherapy (CT) has been added to standard RT to improve outcome in high-risk patients, either as an adjuvant, neoadjuvant or concurrent treatment modality with radiation. Surgery plays an important role in rescuing recurrent or persistent disease after primary (CT)RT. This second part of the review provides a critical analysis of various treatment described in the literature, both for primary cancer and for regional and distant metastases. The prognostic factors and the final results of the various treatments will also be analysed.
期刊介绍：
Acta Otorhinolaryngologica Italica first appeared as “Annali di Laringologia Otologia e Faringologia” and was founded in 1901 by Giulio Masini.
It is the official publication of the Italian Hospital Otology Association (A.O.O.I.) and, since 1976, also of the Società Italiana di Otorinolaringoiatria e Chirurgia Cervico-Facciale (S.I.O.Ch.C.-F.).
The journal publishes original articles (clinical trials, cohort studies, case-control studies, cross-sectional surveys, and diagnostic test assessments) of interest in the field of otorhinolaryngology as well as clinical techniques and technology (a short report of unique or original methods for surgical techniques, medical management or new devices or technology), editorials (including editorial guests – special contribution) and letters to the Editor-in-Chief.
Articles concerning science investigations and well prepared systematic reviews (including meta-analyses) on themes related to basic science, clinical otorhinolaryngology and head and neck surgery have high priority.
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