Anti-inflammatory Effects of Ziziphus Jujube Mill on LPS-induced Acute Lung Injury in Mice.

IF 1.2 4区 医学 Q4 ALLERGY Iranian journal of allergy, asthma, and immunology Pub Date : 2023-06-16 DOI:10.18502/ijaai.v22i3.13056
Parastoo Shaban, Niloofar Honari, Nafiseh Erfanian, Mehran Hosseini, Hossein Safarpour, Saeed Nasseri
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Abstract

Ziziphus Jujuba Mill (Z.J) is a well-known ethnomedical source of biologically active compounds with anti-inflammatory effects. However, its significance in acute lung injury (ALI) has never been studied. The present study aimed to explore whether Z.J could attenuate lipopolysaccharide (LPS)-induced inflammatory responses in an experimental model of ALI. Male BALB/c mice received an intratracheal administration of LPS (n=32) or phosphate buffer saline (PBS) (control, n=8). Within 1, 11, and 23 h post-LPS injection, mice were randomly assigned to receive intraperitoneal treatments of saline, dexamethasone (2 mg/kg), and 100 and 200 mg/kg of Z.J extracts, respectively. 24 h after intratracheal administration of LPS, bronchoalveolar lavage fluid and lung tissues were harvested and assessed for inflammatory cell influx, tumor necrosis factor-α (TNF-α) levels, and histological assessments. Treatment with Z.J extracts (100 and 200 mg/kg) and dexamethasone effectively reduced LPS-induced neutrophil and other inflammatory cell influx into the lung tissue compared to the untreated group. additionally, both doses of Z.J extracts (100 and 200 mg/kg) significantly ameliorated the lung wet-to-dry ratio and histopathological damage. Furthermore, compared to the untreated ALI mice, Z.J extract at the highest dose could significantly reduce the TNF-α level.   The present findings indicated that Z.J could effectively ameliorate LPS-induced ALI inflammatory responses and might be considered a promising alternative therapy for the ALI phenotype.

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红枣粉对lps致小鼠急性肺损伤的抗炎作用。
酸枣粉(Ziziphus Jujuba Mill, Z.J)是一种著名的具有抗炎作用的生物活性化合物的民族医学来源。然而,其在急性肺损伤(ALI)中的意义尚未被研究。本研究旨在探讨Z.J是否可以减轻ALI实验模型中脂多糖(LPS)诱导的炎症反应。雄性BALB/c小鼠气管内注射LPS (n=32)或磷酸盐缓冲盐水(PBS)(对照组,n=8)。在lps注射后1、11和23 h内,小鼠随机分为生理盐水、地塞米松(2 mg/kg)和Z.J提取物100和200 mg/kg腹腔注射组。在气管内给药24小时后,收集支气管肺泡灌洗液和肺组织,评估炎症细胞内流、肿瘤坏死因子-α (TNF-α)水平和组织学评估。与未治疗组相比,Z.J提取物(100和200 mg/kg)和地塞米松治疗有效地减少了lps诱导的中性粒细胞和其他炎症细胞流入肺组织。此外,两种剂量的紫荆提取物(100和200 mg/kg)均可显著改善肺干湿比和组织病理学损伤。此外,与未治疗的ALI小鼠相比,最高剂量的Z.J提取物可显著降低TNF-α水平。本研究结果表明,Z.J可以有效改善lps诱导的ALI炎症反应,可能被认为是一种有希望的ALI表型替代疗法。
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来源期刊
CiteScore
2.60
自引率
6.70%
发文量
64
审稿时长
>12 weeks
期刊介绍: The Iranian Journal of Allergy, Asthma and Immunology (IJAAI), an international peer-reviewed scientific and research journal, seeks to publish original papers, selected review articles, case-based reviews, and other articles of special interest related to the fields of asthma, allergy and immunology. The journal is an official publication of the Iranian Society of Asthma and Allergy (ISAA), which is supported by the Immunology, Asthma and Allergy Research Institute (IAARI) and published by Tehran University of Medical Sciences (TUMS). The journal seeks to provide its readers with the highest quality materials published through a process of careful peer reviews and editorial comments. All papers are published in English.
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