{"title":"WNT5A: a double-edged sword in colorectal cancer progression","authors":"Muhammad Tufail, Changxin Wu","doi":"10.1016/j.mrrev.2023.108465","DOIUrl":null,"url":null,"abstract":"<div><p><span>The Wnt signaling pathway is known to play a crucial role in cancer, and </span><span><em>WNT5A</em></span> is a member of this pathway that binds to the <span><em>Frizzled</em></span> (<em>FZD</em>) and <em>Receptor Tyrosine Kinase-Like Orphan Receptor</em> (<em>ROR</em>) family members to activate non-canonical Wnt signaling pathways. The <em>WNT5A</em><span> pathway is involved in various cellular processes<span>, such as proliferation, differentiation, migration, adhesion, and polarization. In the case of colorectal cancer (CRC), abnormal activation or inhibition of </span></span><em>WNT5A</em> signaling can lead to both oncogenic and antitumor effects. Moreover, <em>WNT5A</em> is associated with inflammation, metastasis, and altered metabolism in cancer cells. This article aims to discuss the molecular mechanisms and dual roles of <em>WNT5A</em> in CRC.</p></div>","PeriodicalId":49789,"journal":{"name":"Mutation Research-Reviews in Mutation Research","volume":"792 ","pages":"Article 108465"},"PeriodicalIF":4.2000,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Mutation Research-Reviews in Mutation Research","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1383574223000133","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOTECHNOLOGY & APPLIED MICROBIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
The Wnt signaling pathway is known to play a crucial role in cancer, and WNT5A is a member of this pathway that binds to the Frizzled (FZD) and Receptor Tyrosine Kinase-Like Orphan Receptor (ROR) family members to activate non-canonical Wnt signaling pathways. The WNT5A pathway is involved in various cellular processes, such as proliferation, differentiation, migration, adhesion, and polarization. In the case of colorectal cancer (CRC), abnormal activation or inhibition of WNT5A signaling can lead to both oncogenic and antitumor effects. Moreover, WNT5A is associated with inflammation, metastasis, and altered metabolism in cancer cells. This article aims to discuss the molecular mechanisms and dual roles of WNT5A in CRC.
期刊介绍：
The subject areas of Reviews in Mutation Research encompass the entire spectrum of the science of mutation research and its applications, with particular emphasis on the relationship between mutation and disease. Thus this section will cover advances in human genome research (including evolving technologies for mutation detection and functional genomics) with applications in clinical genetics, gene therapy and health risk assessment for environmental agents of concern.
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