Impact of medium cut-off membranes on S100A12 and soluble receptor for advanced glycation end products.

IF 1.4 4区医学 Q3 UROLOGY & NEPHROLOGY Seminars in Dialysis Pub Date : 2023-05-01 DOI:10.1111/sdi.13107

Berfu Korucu, Hasan Yeter, Sevim Gonen, Mehmet Kursat Derici, Claudio Ronco, Ulver Derici

引用次数: 2

Abstract

Of the most remarkable molecules associated with atherosclerosis and the cardiovascular outcome are S100A12 (10,379.5 Da) and soluble receptor for advanced glycation end products (sRAGE‐42,803 Da) in the hemodialysis (HD) population. We designed a study investigating the effects of the medium cut‐off (MCO) dialyzers focusing on S100A12 and sRAGE in HD patients compared with low‐flux and high‐flux dialyzers.

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介质切断膜对S100A12和晚期糖基化终产物可溶性受体的影响。

在血液透析(HD)人群中，与动脉粥样硬化和心血管结局相关的最显著分子是S100A12 (10,379.5 Da)和晚期糖基化终产物可溶性受体(sage -42,803 Da)。我们设计了一项研究，研究了以S100A12和sRAGE为重点的中截止(MCO)透析器与低通量和高通量透析器对HD患者的影响。方法:这项单地点、前瞻性、观察性研究包括年龄和性别匹配的HD组(低通量、高通量和MCO)。在基线(透析前和透析后)和第六个月(透析前)抽取血样。结果:各组具有相似的人口学特征和实验室参数。两组的基线S100A12水平相似[34.3(±66.5)，30.9(±42.7)和40.6(±29.6);p = 0.13]。与基线相比，低通量组和高通量组第6个月的S100A12水平不变，MCO组显著降低(p = 0.16, p = 0.33和p = 0.004)。各组的基线sRAGE水平在基线时相似[2.8(±0.8)，2.7(±0.6)和2.6(±0.7);p = 0.65),第六个月[2.9(±0.5),2.4(±0.7),和2.4(±0.8);p = 0.24]。各组sRAGE水平保持不变[p = 0.84, p = 0.13, p = 0.39]。基线和第6个月的S100A12/sRAGE比率在低通量下保持不变[22.3(±63.7)和18.1(±24.8)];P = 0.17]和高通量组[11.9(±15.3)和13.1(±5.8)];p = 0.26]， MCO组的比值明显降低[16.5(±11.6)~ 7.8(±5.5);p = 0.03]。结论:我们的研究表明，长期使用MCO透析器与更好的S100A12和sRAGE水平相关。需要更大样本的长期研究来了解MCO透析器提供的更好的S100A12-sRAGE谱对HD患者心血管结局的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Seminars in Dialysis 医学-泌尿学与肾脏学

CiteScore

3.00

自引率

6.20%

发文量

审稿时长

4-8 weeks

期刊介绍： Seminars in Dialysis is a bimonthly publication focusing exclusively on cutting-edge clinical aspects of dialysis therapy. Besides publishing papers by the most respected names in the field of dialysis, the Journal has unique useful features, all designed to keep you current: -Fellows Forum -Dialysis rounds -Editorials -Opinions -Briefly noted -Summary and Comment -Guest Edited Issues -Special Articles Virtually everything you read in Seminars in Dialysis is written or solicited by the editors after choosing the most effective of nine different editorial styles and formats. They know that facts, speculations, ''how-to-do-it'' information, opinions, and news reports all play important roles in your education and the patient care you provide. Alternate issues of the journal are guest edited and focus on a single clinical topic in dialysis.