16S rRNA gene sequencing reveals the effect of fluoxetine on gut microbiota in chronic unpredictable stress-induced depressive-like rats.

IF 3.6 3区 医学 Q1 PSYCHIATRY Annals of General Psychiatry Pub Date : 2023-08-03 DOI:10.1186/s12991-023-00458-x
Hui Dong, Xiaowei Tang, Jie Ye, Wenhuan Xiao
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Abstract

Objectives: Gut microbiota is relevant to the pathogenesis of mental disorders including depression. This study aimed to investigate the influence of fluoxetine (FLX) on the gut microbiota in rats with Chronic Unpredictable Mild Stresses (CUMS)-induced depression.

Results: We confirmed that the 28-day CUMS-induced depression rat model. Chronic FLX administration weakly improved depressive-like behaviors in rats. Illumina 16S rRNA gene sequencing on rat feces showed CUMS increased the relative abundance of Firmicutes (60.31% vs. 48.09% in Control, p < 0.05) and Lactobacillus genus (21.06% vs. 6.82% in control, p < 0.05); FLX and CUMS increased Bacilli class (20.00% ~ 24.08% vs. 10.31% in control, p < 0.05).

Conclusion: Collectively, our study showed that both CUMS and FLX changed the compositions of gut microbiota in rats. FLX and CUMS distinctly regulated the gut microbiota in depressed rats.

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16S rRNA基因测序揭示了氟西汀对慢性不可预测应激性抑郁样大鼠肠道微生物群的影响。
目的:肠道菌群与抑郁症等精神障碍的发病机制有关。本研究旨在探讨氟西汀(FLX)对慢性不可预知轻度应激(CUMS)抑郁症大鼠肠道微生物群的影响。结果:我们证实了cms诱导的28天抑郁大鼠模型。长期服用FLX能微弱地改善大鼠的抑郁样行为。对大鼠粪便的Illumina 16S rRNA基因测序显示,CUMS增加了厚壁菌门的相对丰度(60.31%,对照组为48.09%)。p结论:我们的研究表明,CUMS和FLX都改变了大鼠肠道微生物群的组成。FLX和CUMS明显调节抑郁大鼠的肠道微生物群。
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来源期刊
CiteScore
6.60
自引率
2.70%
发文量
43
审稿时长
>12 weeks
期刊介绍: Annals of General Psychiatry considers manuscripts on all aspects of psychiatry, including neuroscience and psychological medicine. Both basic and clinical neuroscience contributions are encouraged. Annals of General Psychiatry emphasizes a biopsychosocial approach to illness and health and strongly supports and follows the principles of evidence-based medicine. As an open access journal, Annals of General Psychiatry facilitates the worldwide distribution of high quality psychiatry and mental health research. The journal considers submissions on a wide range of topics including, but not limited to, psychopharmacology, forensic psychiatry, psychotic disorders, psychiatric genetics, and mood and anxiety disorders.
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