{"title":"Targeting NMDA receptor signaling for therapeutic intervention in brain disorders.","authors":"He Chen, Yuanping Dong, Yun Wu, Feng Yi","doi":"10.1515/revneuro-2022-0096","DOIUrl":null,"url":null,"abstract":"<p><p><i>N</i>-Methyl-d-aspartate (NMDA) receptor hyperfunction plays a key role in the pathological processes of depression and neurodegenerative diseases, whereas NMDA receptor hypofunction is implicated in schizophrenia. Considerable efforts have been made to target NMDA receptor function for the therapeutic intervention in those brain disorders. In this mini-review, we first discuss ion flux-dependent NMDA receptor signaling and ion flux-independent NMDA receptor signaling that result from structural rearrangement upon binding of endogenous agonists. Then, we review current strategies for exploring druggable targets of the NMDA receptor signaling and promising future directions, which are poised to result in new therapeutic agents for several brain disorders.</p>","PeriodicalId":49623,"journal":{"name":"Reviews in the Neurosciences","volume":"34 6","pages":"635-647"},"PeriodicalIF":3.4000,"publicationDate":"2023-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Reviews in the Neurosciences","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1515/revneuro-2022-0096","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"NEUROSCIENCES","Score":null,"Total":0}
引用次数: 1
Abstract
N-Methyl-d-aspartate (NMDA) receptor hyperfunction plays a key role in the pathological processes of depression and neurodegenerative diseases, whereas NMDA receptor hypofunction is implicated in schizophrenia. Considerable efforts have been made to target NMDA receptor function for the therapeutic intervention in those brain disorders. In this mini-review, we first discuss ion flux-dependent NMDA receptor signaling and ion flux-independent NMDA receptor signaling that result from structural rearrangement upon binding of endogenous agonists. Then, we review current strategies for exploring druggable targets of the NMDA receptor signaling and promising future directions, which are poised to result in new therapeutic agents for several brain disorders.
n -甲基-d-天冬氨酸(NMDA)受体功能亢进在抑郁症和神经退行性疾病的病理过程中起关键作用，而NMDA受体功能低下与精神分裂症有关。针对NMDA受体功能的治疗干预已经取得了相当大的进展。在这篇综述中，我们首先讨论了内源性激动剂结合后结构重排导致的离子通量依赖性NMDA受体信号传导和离子通量非依赖性NMDA受体信号传导。然后，我们回顾了目前探索NMDA受体信号的可药物靶点的策略和有希望的未来方向，这些靶点有望为几种脑部疾病带来新的治疗药物。
期刊介绍：
Reviews in the Neurosciences provides a forum for reviews, critical evaluations and theoretical treatment of selective topics in the neurosciences. The journal is meant to provide an authoritative reference work for those interested in the structure and functions of the nervous system at all levels of analysis, including the genetic, molecular, cellular, behavioral, cognitive and clinical neurosciences. Contributions should contain a critical appraisal of specific areas and not simply a compilation of published articles.
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