The neuroprotective effects of peracetylated chitosan oligosaccharides against β-amyloid-induced cognitive deficits in rats.

IF 5.8 2区生物学 Q1 MARINE & FRESHWATER BIOLOGY Marine Life Science & Technology Pub Date : 2023-05-22 eCollection Date: 2023-05-01 DOI:10.1007/s42995-023-00172-3

Cui Hao, Minmin Han, Wei Wang, Cheng Yang, Jigang Wang, Yunliang Guo, Tao Xu, Lijuan Zhang, Chunxia Li

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Abstract

Chitosan oligosaccharides (COSs) have been reported to possess a broad range of activities such as antitumor, antioxidant and neuroprotective activities. In this study, the protective effects and mechanisms of peracetylated chitosan oligosaccharides (PACOs) against Aβ-induced cognitive deficits were investigated in Sprague-Dawley (SD) rats. PACOs treatment significantly improved the learning and memory function of Alzheimer's disease (AD) rats and attenuated the neuron cell damage caused by Aβ. PACOs also markedly reduced the levels of lactate dehydrogenase (LDH) and Malondialdehyde (MDA) and decreased the phosphorylation of Tau protein to inhibit oxidative injury and inflammatory responses in AD rats. Further studies indicated that PACOs may promote the repair of Aβ induced nerve damage and inhibit neuronal apoptosis mainly through regulating PI3K/Akt/GSK3β signaling pathway. Consistently, the transcriptome analysis verified that the differentially expressed genes (DEGs) were mainly involved in neuron development and the PI3K-Akt signaling pathway. Taken together, peracetylated chitosan oligosaccharides (PACOs) have the potential to be developed into novel anti-AD agents targeting the cellular PI3K/Akt/GSK3β signaling pathway.

Supplementary information: The online version contains supplementary material available at 10.1007/s42995-023-00172-3.

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过乙酰壳聚糖寡糖对β-淀粉样蛋白诱导的大鼠认知缺陷的神经保护作用。

壳聚糖寡糖（COS）具有广泛的抗肿瘤、抗氧化和神经保护活性。在本研究中，研究了过乙酰壳聚糖寡糖（PACOs）对Sprague-Dawley（SD）大鼠Aβ诱导的认知缺陷的保护作用及其机制。PACOs治疗显著改善了阿尔茨海默病（AD）大鼠的学习记忆功能，减轻了Aβ对神经元细胞的损伤。PACOs还显著降低了AD大鼠的乳酸脱氢酶（LDH）和丙二醛（MDA）水平，并降低了Tau蛋白的磷酸化，以抑制AD大鼠氧化损伤和炎症反应。进一步的研究表明，PACOs可能主要通过调节PI3K/Akt/GSK3β信号通路来促进Aβ诱导的神经损伤的修复并抑制神经元凋亡。一致地，转录组分析证实差异表达基因（DEGs）主要参与神经元发育和PI3K-Akt信号通路。总之，过乙酰化壳聚糖寡糖（PACO）有潜力发展成为靶向细胞PI3K/Akt/GSK3β信号通路的新型抗AD药物。补充信息：在线版本包含补充材料，可访问10.1007/s42995-023-00172-3。

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来源期刊

Marine Life Science & Technology MARINE & FRESHWATER BIOLOGY-

CiteScore

9.60

自引率

10.50%

发文量

期刊介绍： Marine Life Science & Technology (MLST), established in 2019, is dedicated to publishing original research papers that unveil new discoveries and theories spanning a wide spectrum of life sciences and technologies. This includes fundamental biology, fisheries science and technology, medicinal bioresources, food science, biotechnology, ecology, and environmental biology, with a particular focus on marine habitats. The journal is committed to nurturing synergistic interactions among these diverse disciplines, striving to advance multidisciplinary approaches within the scientific field. It caters to a readership comprising biological scientists, aquaculture researchers, marine technologists, biological oceanographers, and ecologists.