Fluid flow to mimic organ function in 3D in vitro models.

IF 6.6 3区 医学 Q1 ENGINEERING, BIOMEDICAL APL Bioengineering Pub Date : 2023-08-04 eCollection Date: 2023-09-01 DOI:10.1063/5.0146000
Yago Juste-Lanas, Silvia Hervas-Raluy, José Manuel García-Aznar, Alejandra González-Loyola
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Abstract

Many different strategies can be found in the literature to model organ physiology, tissue functionality, and disease in vitro; however, most of these models lack the physiological fluid dynamics present in vivo. Here, we highlight the importance of fluid flow for tissue homeostasis, specifically in vessels, other lumen structures, and interstitium, to point out the need of perfusion in current 3D in vitro models. Importantly, the advantages and limitations of the different current experimental fluid-flow setups are discussed. Finally, we shed light on current challenges and future focus of fluid flow models applied to the newest bioengineering state-of-the-art platforms, such as organoids and organ-on-a-chip, as the most sophisticated and physiological preclinical platforms.

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在三维体外模型中模拟器官功能的流体流动。
体外器官生理学、组织功能和疾病模型的文献中有许多不同的策略;然而,这些模型大多缺乏体内的生理流体动力学。在此,我们强调流体流动对组织稳态的重要性,特别是在血管、其他管腔结构和间质中,并指出目前的三维体外模型需要灌注。重要的是,我们讨论了当前不同实验流体流动设置的优势和局限性。最后,我们阐明了将流体流动模型应用于最新生物工程平台(如有机体和芯片器官)的当前挑战和未来重点,这些平台是最复杂和最生理学的临床前平台。
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来源期刊
APL Bioengineering
APL Bioengineering ENGINEERING, BIOMEDICAL-
CiteScore
9.30
自引率
6.70%
发文量
39
审稿时长
19 weeks
期刊介绍: APL Bioengineering is devoted to research at the intersection of biology, physics, and engineering. The journal publishes high-impact manuscripts specific to the understanding and advancement of physics and engineering of biological systems. APL Bioengineering is the new home for the bioengineering and biomedical research communities. APL Bioengineering publishes original research articles, reviews, and perspectives. Topical coverage includes: -Biofabrication and Bioprinting -Biomedical Materials, Sensors, and Imaging -Engineered Living Systems -Cell and Tissue Engineering -Regenerative Medicine -Molecular, Cell, and Tissue Biomechanics -Systems Biology and Computational Biology
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