Markers of liver function as potential prognostic indicators of SARS-CoV-2 infection: A retrospective analysis during the first and second waves of COVID-19 pandemic.

Q2 Medicine Infezioni in Medicina Pub Date : 2023-01-01 DOI:10.53854/liim-3102-9
Ludovica Esposito, Matteo Guarino, Benedetta Perna, Andrea Ciccarone, Alice Eleonora Cesaro, Francesca Manza, Adriana Pretula, Anna Costanzini, Martina Maritati, Elena Forini, Michele Domenico Spampinato, Roberto De Giorgio, Carlo Contini
{"title":"Markers of liver function as potential prognostic indicators of SARS-CoV-2 infection: A retrospective analysis during the first and second waves of COVID-19 pandemic.","authors":"Ludovica Esposito,&nbsp;Matteo Guarino,&nbsp;Benedetta Perna,&nbsp;Andrea Ciccarone,&nbsp;Alice Eleonora Cesaro,&nbsp;Francesca Manza,&nbsp;Adriana Pretula,&nbsp;Anna Costanzini,&nbsp;Martina Maritati,&nbsp;Elena Forini,&nbsp;Michele Domenico Spampinato,&nbsp;Roberto De Giorgio,&nbsp;Carlo Contini","doi":"10.53854/liim-3102-9","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic is known to cause a predominant respiratory disease, although extrapulmonary manifestations can also occur. One of the targets of Coronavirus disease 2019 (COVID-19) is the hepatobiliary system. The present study aims to describe the correlation between the increase of liver damage markers (<i>i.e</i>. alanine aminotransferase [ALT], aspartate aminotransferase [AST], total bilirubin [TB]) and COVID-19 outcomes (<i>i.e</i>., in-hospital mortality [IHM] and intensive care unit [ICU] transfer).</p><p><strong>Methods: </strong>All patients with confirmed SARS-CoV-2 infection admitted to the Infectious Diseases Unit of the St. Anna University-Hospital of Ferrara from March 2020 to October 2021 were retrospectively included in this single-centre study. ALT, AST and TB levels were tested in all patients and IHM or ICU transfer were considered as main outcomes. Co-morbidities were assessed using Charlson Comorbidity Index.</p><p><strong>Results: </strong>A total of 106 patients were retrieved. No hepatic marker was able to predict IHM, whereas all of them negatively predicted ICU transfer (ALT: OR 1.005, 95%CI 1.001-1.009, p= 0.011; AST: OR 1.018, 95%CI 1.006-1.030, p= 0.003; TB: OR 1.329, 95%CI 1.025-1.724, p= 0.032). Age was the only parameter significantly related to mortality.</p><p><strong>Conclusions: </strong>The present study, by correlating liver damage markers with COVID-19 outcome, showed that an increase of ALT, AST and TB predicted patients' severity, although not mortality.</p>","PeriodicalId":52423,"journal":{"name":"Infezioni in Medicina","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10241392/pdf/1124-9390_31_1_2023_209-214.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Infezioni in Medicina","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.53854/liim-3102-9","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0

Abstract

Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic is known to cause a predominant respiratory disease, although extrapulmonary manifestations can also occur. One of the targets of Coronavirus disease 2019 (COVID-19) is the hepatobiliary system. The present study aims to describe the correlation between the increase of liver damage markers (i.e. alanine aminotransferase [ALT], aspartate aminotransferase [AST], total bilirubin [TB]) and COVID-19 outcomes (i.e., in-hospital mortality [IHM] and intensive care unit [ICU] transfer).

Methods: All patients with confirmed SARS-CoV-2 infection admitted to the Infectious Diseases Unit of the St. Anna University-Hospital of Ferrara from March 2020 to October 2021 were retrospectively included in this single-centre study. ALT, AST and TB levels were tested in all patients and IHM or ICU transfer were considered as main outcomes. Co-morbidities were assessed using Charlson Comorbidity Index.

Results: A total of 106 patients were retrieved. No hepatic marker was able to predict IHM, whereas all of them negatively predicted ICU transfer (ALT: OR 1.005, 95%CI 1.001-1.009, p= 0.011; AST: OR 1.018, 95%CI 1.006-1.030, p= 0.003; TB: OR 1.329, 95%CI 1.025-1.724, p= 0.032). Age was the only parameter significantly related to mortality.

Conclusions: The present study, by correlating liver damage markers with COVID-19 outcome, showed that an increase of ALT, AST and TB predicted patients' severity, although not mortality.

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
肝功能标志物作为SARS-CoV-2感染的潜在预后指标:第一波和第二波COVID-19大流行期间的回顾性分析
背景:严重急性呼吸综合征冠状病毒2 (SARS-CoV-2)大流行是已知的主要呼吸道疾病,尽管也可能发生肺外表现。2019冠状病毒病(COVID-19)的目标之一是肝胆系统。本研究旨在探讨肝损伤标志物(如谷丙转氨酶(ALT)、天冬氨酸转氨酶(AST)、总胆红素(TB))升高与COVID-19结局(即住院死亡率(IHM)和重症监护病房(ICU)转院)之间的相关性。方法:回顾性纳入2020年3月至2021年10月在费拉拉圣安娜大学医院传染病科收治的所有确诊的SARS-CoV-2感染患者。所有患者均检测ALT、AST和TB水平,并将IHM或ICU转移视为主要结局。采用Charlson合并症指数评估合并症。结果:共检索到106例患者。肝脏指标均不能预测IHM,但均阴性预测ICU转移(ALT: OR 1.005, 95%CI 1.001 ~ 1.009, p= 0.011;AST: OR 1.018, 95%CI 1.006-1.030, p= 0.003;TB: OR 1.329, 95%CI 1.025-1.724, p= 0.032)。年龄是唯一与死亡率显著相关的参数。结论:本研究通过将肝损伤标志物与COVID-19预后相关联,表明ALT、AST和TB的升高预测了患者的严重程度,但不能预测死亡率。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
Infezioni in Medicina
Infezioni in Medicina Medicine-Infectious Diseases
CiteScore
8.40
自引率
0.00%
发文量
62
期刊介绍: The Journal publishes original papers, in Italian or in English, on topics concerning aetiopathogenesis, prevention, epidemiology, diagnosis, clinical features and therapy of infections, whose acceptance is subject to the referee’s assessment. The Journal is of interest not only to infectious disease specialists, microbiologists and pharmacologists, but also to internal medicine specialists, paediatricians, pneumologists, and to surgeons as well. The Editorial Board includes experts in each of the above mentioned fields.
期刊最新文献
The current state of knowledge on dracunculiasis: a narrative review of a rare neglected disease Historical account of clinical observations on leprosy and related manifestations in the Comacchio area, Italy, in the XIX century Clinical utility of intrabronchial antifungal instillation in a complicated case of chronic pulmonary aspergillosis: case report and systematic review of literature Did the updated Duke criteria missed Erysipelothrix rhusiopathiae from the list of typical microorganisms causing infective endocarditis? The role of long-acting antibiotics in the clinical practice: a narrative review
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1