Serial feature positive and feature negative discrimination learning in a taste avoidance preparation: implications for interoceptive control of behavior.

IF 1.6 4区 心理学 Q3 BEHAVIORAL SCIENCES Behavioural Pharmacology Pub Date : 2023-09-01 DOI:10.1097/FBP.0000000000000741
Shihui Huang, Sydney E Cerveny, Anna L Ruprecht, Ethan R Steere, Terry L Davidson, Anthony L Riley
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Abstract

Background: Psychoactive drugs produce interoceptive stimuli that can guide appropriate behaviors by initiating or inhibiting responding.

Objective: The current study investigated whether an interoceptive morphine state produces similar patterns of serial feature positive (FP) and feature negative (FN) discrimination learning under comparable conditions in a taste avoidance design.

Methods: Male Sprague-Dawley rats were trained under 10 cycles of FP or FN discrimination. In the FP task, morphine (10 mg/kg, IP) signaled that a saccharin solution was followed by LiCl (1.2 mEq, IP), while the vehicle (saline) signaled that the LiCl was withheld. In the FN task, the contingency was reversed.

Results: The FP-trained rats acquired the discrimination after three training cycles, consuming significantly less saccharin on morphine, than on vehicle, sessions ( P  < 0.05). The FN-trained rats acquired the discrimination after six training cycles, consuming more on morphine than on vehicle sessions ( P < 0.05). However, FN-trained rats never recovered saccharin consumption to baseline levels and 40% of the rats continued to avoid saccharin (consuming 0 ml) on morphine sessions. Control rats that never received LiCl consumed high levels of saccharin on morphine and vehicle sessions, indicating that morphine did not produce unconditioned suppression of saccharin consumption.

Conclusion: The difficulty to acquire FN discrimination might reflect the limitations of learning about safety contingencies in the taste avoidance design. The rapidity of FP learning when a drug state signals an aversive contingency may have implications for the general role of interoceptive stimuli in the control of behavior.

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味觉回避准备中的系列特征积极和特征消极辨别学习:对行为内感受控制的影响。
背景:精神活性药物产生内感受性刺激,通过启动或抑制反应来引导适当的行为。目的:本研究探讨了在可比较条件下,在味觉回避设计中,吗啡的内感受性状态是否会产生相似的序列特征阳性(FP)和特征阴性(FN)辨别学习模式。方法:对雄性Sprague-Dawley大鼠进行FP或FN识别10个周期的训练。在FP任务中,吗啡(10 mg/kg, IP)表示糖精溶液后加入LiCl (1.2 mEq, IP),而载药(生理盐水)表示LiCl被保留。在FN任务中,偶然性是相反的。结果:经过3个训练周期后,接受fp训练的大鼠获得了辨别能力,吗啡组的糖精消耗明显少于车辆组(P)。结论:获得FN辨别能力的困难可能反映了味觉回避设计中安全意外事件学习的局限性。当药物状态预示着厌恶偶然性时,FP学习的速度可能暗示了内感受性刺激在行为控制中的一般作用。
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来源期刊
Behavioural Pharmacology
Behavioural Pharmacology 医学-行为科学
CiteScore
3.40
自引率
0.00%
发文量
84
审稿时长
6-12 weeks
期刊介绍: Behavioural Pharmacology accepts original full and short research reports in diverse areas ranging from ethopharmacology to the pharmacology of schedule-controlled operant behaviour, provided that their primary focus is behavioural. Suitable topics include drug, chemical and hormonal effects on behaviour, the neurochemical mechanisms under-lying behaviour, and behavioural methods for the study of drug action. Both animal and human studies are welcome; however, studies reporting neurochemical data should have a predominantly behavioural focus, and human studies should not consist exclusively of clinical trials or case reports. Preference is given to studies that demonstrate and develop the potential of behavioural methods, and to papers reporting findings of direct relevance to clinical problems. Papers making a significant theoretical contribution are particularly welcome and, where possible and merited, space is made available for authors to explore fully the theoretical implications of their findings. Reviews of an area of the literature or at an appropriate stage in the development of an author’s own work are welcome. Commentaries in areas of current interest are also considered for publication, as are Reviews and Commentaries in areas outside behavioural pharmacology, but of importance and interest to behavioural pharmacologists. Behavioural Pharmacology publishes frequent Special Issues on current hot topics. The editors welcome correspondence about whether a paper in preparation might be suitable for inclusion in a Special Issue.
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