Pharmacological and non-pharmacological countermeasures to Space Motion Sickness: a systematic review.

IF 3.4 3区医学 Q2 NEUROSCIENCES Frontiers in Neural Circuits Pub Date : 2023-01-01 DOI:10.3389/fncir.2023.1150233

Akil Khalid, Pragnya P Prusty, Iqra Arshad, Hannah E Gustafson, Isra Jalaly, Keith Nockels, Barry L Bentley, Rahul Goel, Elisa R Ferrè

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引用次数: 1

Abstract

Introduction: Space Motion Sickness (SMS) is a syndrome that affects around 70% of astronauts and includes symptoms of nausea, dizziness, fatigue, vertigo, headaches, vomiting, and cold sweating. Consequences range from discomfort to severe sensorimotor and cognitive incapacitation, which might cause potential problems for mission-critical tasks and astronauts and cosmonauts' well-being. Both pharmacological and non-pharmacological countermeasures have been proposed to mitigate SMS. However, their effectiveness has not been systematically evaluated. Here we present the first systematic review of published peer-reviewed research on the effectiveness of pharmacological and non-pharmacological countermeasures to SMS.

Methods: We performed a double-blind title and abstract screening using the online Rayyan collaboration tool for systematic reviews, followed by a full-text screening. Eventually, only 23 peer-reviewed studies underwent data extraction.

Results: Both pharmacological and non-pharmacological countermeasures can help mitigate SMS symptoms.

Discussion: No definitive recommendation can be given regarding the superiority of any particular countermeasure approach. Importantly, there is considerable heterogeneity in the published research methods, lack of a standardized assessment approach, and small sample sizes. To allow for consistent comparisons between SMS countermeasures in the future, standardized testing protocols for spaceflight and ground-based analogs are needed. We believe that the data should be made openly available, given the uniqueness of the environment in which it is collected.

Systematic review registration: https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42021244131.

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太空晕动病的药物和非药物对策:系统综述。

简介:太空晕动病(SMS)是一种影响约70%宇航员的综合征，症状包括恶心、头晕、疲劳、眩晕、头痛、呕吐和冷汗。后果包括从不适到严重的感觉运动和认知能力丧失，这可能会对关键任务和宇航员的健康造成潜在问题。已经提出了缓解SMS的药理学和非药理学对策。然而，其有效性尚未得到系统评价。在这里，我们提出了第一个系统回顾发表的同行评议研究的有效性药理学和非药理学对策SMS。方法:我们使用在线Rayyan协作工具进行系统评价的双盲标题和摘要筛选，然后进行全文筛选。最终，只有23项同行评议的研究进行了数据提取。结果:药物和非药物对策均有助于缓解SMS症状。讨论:对于任何特定对策方法的优越性，不能给出明确的建议。重要的是，已发表的研究方法存在相当大的异质性，缺乏标准化的评估方法，样本量小。为了允许在未来对SMS对抗措施进行一致的比较，需要针对航天和地面模拟的标准化测试协议。我们认为，鉴于收集数据的环境的独特性，这些数据应该公开提供。系统评审注册:https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42021244131。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Frontiers in Neural Circuits NEUROSCIENCES-

CiteScore

6.00

自引率

5.70%

发文量

135

审稿时长

4-8 weeks

期刊介绍： Frontiers in Neural Circuits publishes rigorously peer-reviewed research on the emergent properties of neural circuits - the elementary modules of the brain. Specialty Chief Editors Takao K. Hensch and Edward Ruthazer at Harvard University and McGill University respectively, are supported by an outstanding Editorial Board of international experts. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics and the public worldwide. Frontiers in Neural Circuits launched in 2011 with great success and remains a "central watering hole" for research in neural circuits, serving the community worldwide to share data, ideas and inspiration. Articles revealing the anatomy, physiology, development or function of any neural circuitry in any species (from sponges to humans) are welcome. Our common thread seeks the computational strategies used by different circuits to link their structure with function (perceptual, motor, or internal), the general rules by which they operate, and how their particular designs lead to the emergence of complex properties and behaviors. Submissions focused on synaptic, cellular and connectivity principles in neural microcircuits using multidisciplinary approaches, especially newer molecular, developmental and genetic tools, are encouraged. Studies with an evolutionary perspective to better understand how circuit design and capabilities evolved to produce progressively more complex properties and behaviors are especially welcome. The journal is further interested in research revealing how plasticity shapes the structural and functional architecture of neural circuits.