Offspring epigenetic markers at birth related to gestational BMI predict offspring BMI-trajectories from infancy to 26 years.

IF 1.9 Q3 ENDOCRINOLOGY & METABOLISM Obesity Science & Practice Pub Date : 2023-08-01 DOI:10.1002/osp4.660

Vimala Devi Janjanam, Susan Ewart, Hongmei Zhang, Yu Jiang, Hasan Arshad, Ali H Ziyab, Wilfried Karmaus

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Abstract

Objective: To date, epigenetic studies identified differential DNA methylation (DNAm) related to gestational-body mass index (BMI) in offspring at birth. This study investigated whether the identified DNAm in offspring were also associated with BMI trajectories from infancy to age 26 years.

Methods: Data of 794 participants from Isle of Wight birth cohort in UK were investigated to study association between BMI trajectories and DNAm related to gestational-BMI at birth. Multinominal logistic regression models were applied to test the association between 1090 DNAm sites reported in three prior epigenome-wide association studies and BMI trajectories.

Results: DNAm site cg23089913 (NANOS1) and cg13217064 (SOX14) were associated with early persistent obesity (EPO) and delayed overweight (DOW) trajectories respectively. A higher methylation of cg23089913 showed low odds of being in EPO trajectory (OR: 0.84; 95% CI: 0.76-0.93) while higher methylation of cg13217064 resulted in 1.4-times the odds of being in DOW trajectory when compared to the normal trajectory [Correction added on 22 February 2023, after first online publication: Range of the DNAm site cg23089913 has been changed from 'lower' to 'higher' in the preceding sentence.]. In a gender-stratified analysis, the odds of developing into DOW was 1.8 times in female participants for cg13217064 while not such association was observed in males.

Conclusions: Deviations in methylation of cg23089913 (NANOS1) and cg13217064 (SOX14) in newborns may change the risk of having excess body weight.

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出生时与妊娠期BMI相关的后代表观遗传标记可以预测后代从婴儿期到26岁的BMI轨迹。

目的:迄今为止，表观遗传学研究发现，差异DNA甲基化(DNAm)与出生时后代的妊娠体重指数(BMI)有关。这项研究调查了后代中确定的dna是否也与婴儿至26岁的BMI轨迹有关。方法:对来自英国怀特岛出生队列的794名参与者的数据进行调查，研究体重指数轨迹与出生时妊娠期体重指数相关的DNAm之间的关系。多项逻辑回归模型被应用于测试之前三个全表观基因组关联研究中报道的1090个DNAm位点与BMI轨迹之间的关联。结果:DNAm位点cg23089913 (NANOS1)和cg13217064 (SOX14)分别与早期持续性肥胖(EPO)和延迟性超重(DOW)轨迹相关。高甲基化的cg23089913显示EPO轨迹的几率较低(OR: 0.84;95% CI: 0.76-0.93)，而cg13217064的高甲基化导致与正常轨迹相比，处于DOW轨迹的几率为1.4倍[在首次在线发表后，于2023年2月22日添加的更正:DNAm位点cg23089913的范围已在前一句中从“较低”改为“较高”。]在性别分层分析中，cg13217064的女性参与者发展为DOW的几率是1.8倍，而在男性中没有观察到这种关联。结论:新生儿中cg23089913 (NANOS1)和cg13217064 (SOX14)甲基化的偏差可能改变体重超标的风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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