Diagnostic Importance of PAX2, ARID1A, and FOXA1 Biomarkers in Atypical Endometrial Hyperplasia.

IF 0.7 4区医学 Q3 MEDICINE, GENERAL & INTERNAL Jcpsp-Journal of the College of Physicians and Surgeons Pakistan Pub Date : 2023-08-01 DOI:10.29271/jcpsp.2023.08.847

Ozlem Nur Yildiz, Cumhur Selcuk Topal, Itir Ebru Zemheri

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Abstract

Objective: To evaluate the contribution of PAX2, ARID1A, and FOXA1 biomarkers to diagnosis in cases with atypical endometrial hyperplasia (AEH).

Study design: Descriptive Study. Place and Duration of the Study: Pathology Department of Umraniye Training and Research Hospital, from January 2018 to December 2020.

Methodology: Curettage materials of 100 patients diagnosed with AEH which stained PAX2, ARID1A, and FOXA1, were evaluated. The staining patterns in the atypical endometrial glandular areas were grouped as slight-no loss, moderate loss, and complete loss / severe loss for all three biomarkers. Complete or/severe loss in AEH was considered helpful in the diagnosis.

Results: Complete loss / severe loss rates in curettages were 84% for PAX2, 5% for ARID1A, and 15% for FOXA1, respectively. When used in combination, complete loss / severe loss rates were 85% in at least one of the three markers, 84% in PAX2 and/or ARID1A, 85% in PAX2 and/or FOXA1, and 17% in ARID1A and/or FOXA1.

Conclusion: Although all 3 biomarkers showed marked staining loss, PAX2 is the most sensitive biomarker for the diagnosis of AEH in curettage materials.

Key words: Endometrium, Atypical hyperplasia, PAX2, ARID1A, FOXA1.

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PAX2、ARID1A和FOXA1生物标志物在非典型子宫内膜增生中的诊断意义

目的:探讨PAX2、ARID1A和FOXA1生物标志物对非典型子宫内膜增生(AEH)的诊断价值。研究设计:描述性研究。研究地点和时间:乌姆拉尼耶培训和研究医院病理科，2018年1月至2020年12月。方法:对100例确诊为AEH患者PAX2、ARID1A和FOXA1染色的刮痧材料进行评价。在非典型子宫内膜腺区，三种生物标志物的染色模式分为轻度无损失、中度损失和完全损失/严重损失。AEH完全或/严重丢失被认为有助于诊断。结果:PAX2的完全丢失/严重丢失率为84%，ARID1A为5%，FOXA1为15%。当联合使用时，三种标记中至少一种的完全丢失/严重丢失率为85%，PAX2和/或ARID1A为84%，PAX2和/或FOXA1为85%，ARID1A和/或FOXA1为17%。结论:虽然3种生物标志物均有明显的染色丢失，但PAX2是诊断刮膜材料AEH最敏感的生物标志物。关键词:子宫内膜，不典型增生，PAX2, ARID1A, FOXA1

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来源期刊

Jcpsp-Journal of the College of Physicians and Surgeons Pakistan MEDICINE, GENERAL & INTERNAL-

CiteScore

1.40

自引率

0.00%

发文量

453

审稿时长

3-6 weeks

期刊介绍： Journal of College of Physicians and Surgeons Pakistan (JCPSP), is the prestigious, peer reviewed monthly biomedical journal of the country published regularly since 1991. Established with the primary aim of promotion and dissemination of medical research and contributed by scholars of biomedical sciences from Pakistan and abroad, it carries original research papers, , case reports, review articles, articles on medical education, commentaries, short communication, new technology, editorials and letters to the editor. It covers the core biomedical health science subjects, basic medical sciences and emerging community problems, prepared in accordance with the “Uniform requirements for submission to bio-medical journals” laid down by International Committee of Medical Journals Editors (ICMJE). All publications of JCPSP are peer reviewed by subject specialists from Pakistan and locally and abroad.