Exosome-derived long noncoding RNAs: Mediators of host-Plasmodium parasite communication.

IF 6.4 2区 生物学 Q1 CELL BIOLOGY Wiley Interdisciplinary Reviews: RNA Pub Date : 2023-08-08 DOI:10.1002/wrna.1808
Jin-Guang Chen, Shuang-Chun Liu, Qing Nie, Yun-Ting Du, Yin-Yi Lv, Lian-Ping He, Guang Chen
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Abstract

Overcoming challenges associated with malaria eradication proves to be a formidable task due to the complicated life cycle exhibited by the malaria parasite and the lack of safe and enduring vaccines against malaria. Investigating the interplay between Plasmodium parasites and their mammalian hosts is crucial for the development of novel vaccines. Long noncoding RNAs (lncRNAs) derived from Plasmodium parasites or host cells have emerged as potential signaling molecules involved in the trafficking of proteins, RNA (mRNAs, miRNAs, and ncRNAs), and DNA. These lncRNAs facilitate the interaction between hosts and parasites, impacting normal physiology or pathology in malaria-infected individuals. Moreover, they possess the capacity to regulate immune responses and associated signaling pathways, thus potentially influencing chromatin organization, epigenetic modifications, mRNA processing, splicing, and translation. However, the functional role of exosomal lncRNAs in malaria remains poorly understood. This review offers a comprehensive analysis of lncRNA and exosomal lncRNA profiles during malaria infection. It presents an overview of recent progress in elucidating the involvement of exosomal lncRNAs in host-parasite interactions. Additionally, potential exosomal lncRNAs linked to the domains of innate and adaptive immunity in the context of malaria are proposed. These findings may contribute to the discovery of new diagnostic and therapeutic strategies for malaria. Furthermore, the need for additional research was highlighted that aimed to elucidate the mechanisms underlying lncRNA transportation into host cells and their targeting of specific genes to regulate the host's immune response. This knowledge gap presents an opportunity for future investigations, offering innovative approaches to enhance malarial control. This article is categorized under: RNA Interactions with Proteins and Other Molecules > Small Molecule-RNA Interactions RNA Interactions with Proteins and Other Molecules > Protein-RNA Interactions: Functional Implications RNA in Disease and Development > RNA in Disease.

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外泌体衍生的长链非编码rna:宿主-疟原虫交流的介质。
克服与消灭疟疾有关的挑战证明是一项艰巨的任务,因为疟疾寄生虫表现出复杂的生命周期,而且缺乏安全和持久的疟疾疫苗。研究疟原虫与其哺乳动物宿主之间的相互作用对于开发新型疫苗至关重要。来自疟原虫寄生虫或宿主细胞的长链非编码RNA (lncRNAs)已成为参与蛋白质、RNA (mrna、miRNAs和ncRNAs)和DNA运输的潜在信号分子。这些lncrna促进宿主和寄生虫之间的相互作用,影响疟疾感染个体的正常生理或病理。此外,它们具有调节免疫应答和相关信号通路的能力,从而潜在地影响染色质组织、表观遗传修饰、mRNA加工、剪接和翻译。然而,外泌体lncrna在疟疾中的功能作用仍然知之甚少。本文综述了疟疾感染期间lncRNA和外泌体lncRNA谱的全面分析。它概述了最近在阐明外泌体lncrna参与宿主-寄生虫相互作用方面的进展。此外,研究人员还提出了与疟疾先天免疫和适应性免疫结构域相关的潜在外泌体lncrna。这些发现可能有助于发现新的疟疾诊断和治疗策略。此外,还需要进一步的研究,以阐明lncRNA转运到宿主细胞及其靶向特定基因以调节宿主免疫反应的机制。这一知识差距为今后的调查提供了机会,为加强疟疾控制提供了创新方法。本文分类如下:RNA与蛋白质和其他分子的相互作用>小分子-RNA相互作用>蛋白质和其他分子的RNA相互作用>蛋白质-RNA相互作用:RNA在疾病和发展中的功能含义> RNA在疾病中的作用。
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来源期刊
CiteScore
14.80
自引率
4.10%
发文量
67
审稿时长
6-12 weeks
期刊介绍: WIREs RNA aims to provide comprehensive, up-to-date, and coherent coverage of this interesting and growing field, providing a framework for both RNA experts and interdisciplinary researchers to not only gain perspective in areas of RNA biology, but to generate new insights and applications as well. Major topics to be covered are: RNA Structure and Dynamics; RNA Evolution and Genomics; RNA-Based Catalysis; RNA Interactions with Proteins and Other Molecules; Translation; RNA Processing; RNA Export/Localization; RNA Turnover and Surveillance; Regulatory RNAs/RNAi/Riboswitches; RNA in Disease and Development; and RNA Methods.
期刊最新文献
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