Transplantation of Bone Marrow Cells Preactivated With Sodium Nitroprusside Improves Acute Wound Healing in Rabbits.

IF 1.5 4区医学 Q3 DERMATOLOGY International Journal of Lower Extremity Wounds Pub Date : 2023-09-01 DOI:10.1177/15347346211029078

Nazira Fatima, Muhammad Saleem

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引用次数: 2

Abstract

The development of wound healing impairment mainly represents challenging clinical problems. The less and high concentrations of nitric oxide can influence angiogenesis, remodeling, and proliferation of skin cells. Delayed acute wounds generally have failed to progress via the normal stages of healing. Such wounds usually enter a state of pathological inflammation due to a postponed, incomplete, and uncoordinated healing process. This study aimed to investigate the effect of normal bone marrow cells (BMCs) and preconditioning of BMCs with minimum concentrations of sodium nitroprusside (NaNP) solution for acute wound healing. For acute wound healing, full-thickness dorsal wounds were created on rabbits. The acute wound of rabbits was treated with BMCs and preactivated BMCs with NaNP. Histological results showed that BMCs preactivated with NaNP could improve collagen deposition, enhanced reepithelization, and decreased inflammatory infiltration. Overall, BMCs treated with NaNP can help to improve acute wound healing in rabbits. The result strongly confirmed the beneficial effect in augmenting the wound healing process. The combination of BMCs with NaNP was safe and convenient for acute wound healing.

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硝普钠预活化骨髓细胞移植促进兔急性伤口愈合。

伤口愈合损伤的发展主要是具有挑战性的临床问题。一氧化氮浓度的高低会影响皮肤细胞的血管生成、重塑和增殖。延迟性急性伤口通常不能通过正常的愈合阶段进展。由于愈合过程的延迟、不完整和不协调，这种伤口通常进入病理性炎症状态。本研究旨在探讨正常骨髓细胞(BMCs)和低浓度硝普钠(NaNP)预处理BMCs对急性伤口愈合的影响。为了急性创面愈合，在家兔背部制造全层创面。用bmc和NaNP预激活bmc治疗兔急性创面。组织学结果显示，用NaNP预活化BMCs可改善胶原沉积，增强再上皮，减少炎症浸润。总的来说，用NaNP处理bmc可以帮助改善兔急性伤口愈合。结果有力地证实了其在促进伤口愈合过程中的有益作用。bmc与NaNP联合应用对急性创面愈合安全、方便。

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来源期刊

International Journal of Lower Extremity Wounds DERMATOLOGY-SURGERY

CiteScore

4.60

自引率

17.60%

发文量

审稿时长

>12 weeks

期刊介绍： The International Journal of Lower Extremity Wounds (IJLEW) is a quarterly, peer-reviewed journal publishing original research, reviews of evidence-based diagnostic techniques and methods, disease and patient management, and surgical and medical therapeutics for lower extremity wounds such as burns, stomas, ulcers, fistulas, and traumatic wounds. IJLEW also offers evaluations of assessment and monitoring tools, dressings, gels, cleansers, pressure management, footwear/orthotics, casting, and bioengineered skin. This journal is a member of the Committee on Publication Ethics (COPE).