The correlation between serum uric acid and diabetic kidney disease in adult-onset type 1 diabetes patients in China

IF 3.1 3区医学 Q2 ENDOCRINOLOGY & METABOLISM Acta Diabetologica Pub Date : 2023-06-01 DOI:10.1007/s00592-023-02119-7

Jun Jiang, Xiaowan Zhou, Lei Lan, Jianping Weng, Wei Ren

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Abstract

Background/aim

To assess the correlation between serum uric acid (UA) level and diabetic kidney disease among adult-onset Type 1 diabetes mellitus (T1DM) patients in China.

Methods

A total of 184 patients with adult-onset T1DM between January 2014 and December 2016 were recruited, with demographics and medical data collected. Comparisons were performed between according to different serum UA gender-specific quartiles. Relationship between serum UA level with urinary ACR and eGFR was also assessed.

Results

Median urinary ACR and eGFR were 21.55 [10.79, 45.02] mg/g and 113.86 [88.43, 143.61] ml/min/1.73 m², respectively. The median UA was 257.4 (208.2–334.8) μmol/L. Participants with higher serum UA levels had higher urinary ACR and lower eGFR than those with lower UA (P < 0.05). Higher serum UA level was significantly associated with higher urinary ACR in Spearman's correlational analysis (P = 0.006) and multiple stepwise regression analysis (P = 0.013). The association between serum UA and urinary ACR was not linear, but showed a curve correlation, which also showed in the sensitivity analysis. Serum UA in the upper gender-specific quartile, was associated with lower eGFR (P < 0.001) and showed an independent negative correlation with eGFR in multiple stepwise regression analysis (P < 0.001).

Conclusions

The serum UA level was negatively correlated with eGFR and had a curve correlation with urinary ACR in adult-onset T1DM patients of China.

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中国成人1型糖尿病患者血清尿酸与糖尿病肾病的相关性

背景/目的评估中国成年1型糖尿病（T1DM）患者血清尿酸（UA）水平与糖尿病肾病的相关性。方法收集2014年1月至2016年12月期间184例成年T1DM患者的人口统计学和医学数据。根据不同的血清UA性别特异性四分位数进行比较。还评估了血清UA水平与尿ACR和eGFR之间的关系。结果中位尿ACR和eGFR分别为21.55[10.79，45.02]mg/g和113.86[88.43，143.61]ml/min/1.73m2。中位UA为257.4（208.2–334.8）μmol/L。血清UA水平较高的参与者比UA水平较低的参与者具有较高的尿ACR和较低的eGFR（P <；血清UA水平升高与尿ACR升高有显著相关性（P = 0.006）和多元逐步回归分析（P = 0.013）。血清UA与尿ACR之间的相关性不是线性的，而是呈曲线相关性，敏感性分析也表明了这一点。血清UA在较高的性别特异性四分位数与较低的eGFR相关（P <； 0.001），与eGFR呈独立负相关（P <；结论中国成年T1DM患者血清UA水平与eGFR呈负相关，与尿ACR呈曲线相关。

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来源期刊

Acta Diabetologica 医学-内分泌学与代谢

CiteScore

7.30

自引率

2.60%

发文量

180

审稿时长

2 months

期刊介绍： Acta Diabetologica is a journal that publishes reports of experimental and clinical research on diabetes mellitus and related metabolic diseases. Original contributions on biochemical, physiological, pathophysiological and clinical aspects of research on diabetes and metabolic diseases are welcome. Reports are published in the form of original articles, short communications and letters to the editor. Invited reviews and editorials are also published. A Methodology forum, which publishes contributions on methodological aspects of diabetes in vivo and in vitro, is also available. The Editor-in-chief will be pleased to consider articles describing new techniques (e.g., new transplantation methods, metabolic models), of innovative importance in the field of diabetes/metabolism. Finally, workshop reports are also welcome in Acta Diabetologica.