H Martin Kramer, David E Cook, Michael F Seidl, Bart P H J Thomma
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引用次数: 0
Abstract
Through the association of protein complexes to DNA, the eukaryotic nuclear genome is broadly organized into open euchromatin that is accessible for enzymes acting on DNA and condensed heterochromatin that is inaccessible. Chemical and physical alterations to chromatin may impact its organization and functionality and are therefore important regulators of nuclear processes. Studies in various fungal plant pathogens have uncovered an association between chromatin organization and expression of in planta-induced genes that are important for pathogenicity. This review discusses chromatin-based regulation mechanisms as determined in the fungal plant pathogen Verticillium dahliae and relates the importance of epigenetic transcriptional regulation and other nuclear processes more broadly in fungal plant pathogens.
通过蛋白质复合物与 DNA 的结合，真核生物的核基因组被广泛地组织成开放的外染色质和凝集的异染色质，前者可供作用于 DNA 的酶使用，后者则无法使用。染色质的化学和物理变化可能会影响其组织和功能，因此是核过程的重要调节因子。对各种真菌植物病原体的研究发现，染色质组织与植物诱导基因的表达之间存在关联，而植物诱导基因对致病性非常重要。本综述讨论了在真菌植物病原体大丽轮枝菌（Verticillium dahliae）中确定的基于染色质的调控机制，并更广泛地阐述了表观遗传转录调控和其他核过程在真菌植物病原体中的重要性。
期刊介绍：
Bacteria, fungi, parasites, prions and viruses cause a plethora of diseases that have important medical, agricultural, and economic consequences. Moreover, the study of microbes continues to provide novel insights into such fundamental processes as the molecular basis of cellular and organismal function.
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