Capparis spinosa Promoted BDNF and Antioxidant Enzyme Levels to Protect Against Learning and Memory Deficits Induced by Scopolamine.

Q3 Psychology Central nervous system agents in medicinal chemistry Pub Date : 2023-01-01 DOI:10.2174/1871524923666230719121439

Mahmoud Hosseini, Fatemeh Mansouritorghabeh, Farimah Beheshti, Fatemeh Shahidpour, Fatemeh Forouzanfar, Arezoo Rajabian

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Abstract

Background: Alzheimer's disease (AD) is a major neurodegenerative disorder with multiple manifestations, including oxidative stress, brain-derived neurotrophic factor (BDNF) depletion, and cholinergic dysfunction. Capparis spinosa (C. spinosa) is identified as a potential source of nutrition for alleviating various ailments. The current study assessed the ameliorating properties of C. spinosa hydroethanolic extract on memory dysfunction and the possible roles of oxidative stress and BDNF in the scopolamine (Scop)-treated rats.

Methods: Forty male Wistar rats were divided into the following four groups: Control, Scop (2 mg/kg, intraperitoneal injection (i.p.)), Scop + C. spinosa 150, and Scop + C. spinosa 300 groups. The rats were given C. spinosa extract (150 or 300 mg/kg, oral) for 3 weeks. During the third week, Passive Avoidance (PA) and Morris Water Maze (MWM) tests were done to assess memory and learning performance. Finally, oxidative stress markers and BDNF in the brain tissue were evaluated.

Results: Scop injection was associated with a significant increase in the time latency and travelled distance to reach the platform during the learning phase of MWM In the probe test, the Scoptreated rats showed a lower time and distance in the target area. Furthermore, Scop injection significantly decreased the latency to enter the dark while increasing the dark time and the frequency of entries to the dark zone of the PA task. C. spinosa extract effectively reversed the behavioural changes induced by Scop. Treatment with the extract also significantly increased the levels of superoxide dismutase, catalase, thiols, and BDNF, while decreasing malondialdehyde production in the brains of the Scop-injured rats.

Conclusion: C. spinosa hydroethanolic extract successfully ameliorated Scop-induced memory impairment by modifying BDNF and oxidative stress markers in the brain of amnesic rats.

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刺山柑提高BDNF和抗氧化酶水平，防止东莨菪碱诱导的学习记忆缺陷。

背景：阿尔茨海默病（AD）是一种主要的神经退行性疾病，有多种表现，包括氧化应激、脑源性神经营养因子（BDNF）耗竭和胆碱能功能障碍。刺山柑（C.spinosa）被认为是缓解各种疾病的潜在营养来源。本研究评估了刺五加水乙醇提取物对东莨菪碱（Scop）治疗大鼠记忆功能障碍的改善作用以及氧化应激和BDNF的可能作用。方法：40只雄性Wistar大鼠分为以下四组：对照组、Scop（2mg/kg，腹膜内注射）组、Scop+C.spinosa 150组和Scop+C.spinosa 300组。对大鼠给予棘皮梭菌提取物（150或300mg/kg，口服）3周。在第三周，进行了被动回避（PA）和莫里斯水迷宫（MWM）测试，以评估记忆和学习表现。最后，对脑组织中的氧化应激标志物和BDNF进行了评估。结果：在MWM的学习阶段，Scop注射与到达平台的时间延迟和行进距离显著增加有关。在探针测试中，Scop治疗的大鼠在目标区域的时间和距离较低。此外，Scop注射显著降低了进入黑暗的延迟，同时增加了进入PA任务的黑暗区域的黑暗时间和频率。刺五加提取物有效地逆转了Scop引起的行为变化。提取物处理还显著提高了Scop损伤大鼠大脑中超氧化物歧化酶、过氧化氢酶、硫醇和BDNF的水平，同时降低了丙二醛的产生。结论：刺五加水乙醇提取物通过修饰健忘症大鼠脑内BDNF和氧化应激标志物，成功地改善了Scop诱导的记忆障碍。

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来源期刊

Central nervous system agents in medicinal chemistry Psychology-Neuropsychology and Physiological Psychology

CiteScore

2.10

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0.00%

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期刊介绍： Central Nervous System Agents in Medicinal Chemistry aims to cover all the latest and outstanding developments in medicinal chemistry and rational drug design for the discovery of new central nervous system agents. Containing a series of timely in-depth reviews written by leaders in the field covering a range of current topics, Central Nervous System Agents in Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments in the field.