Emotional Modulation of Response Inhibition in Adolescents During Acute Suicidal Crisis: Event-Related Potentials in an Emotional Go/NoGo Task.

IF 1.6 4区 医学 Q3 CLINICAL NEUROLOGY Clinical EEG and Neuroscience Pub Date : 2023-09-01 DOI:10.1177/15500594211063311
Meggan Porteous, Paniz Tavakoli, Kenneth Campbell, Allyson Dale, Addo Boafo, Rebecca Robillard
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引用次数: 2

Abstract

Objectives. Suicide is the second leading cause of adolescent deaths and may be linked to difficulties with inhibitory and emotional processing. This study assessed the neural correlates of cognitive inhibition during emotional processing in adolescents hospitalized for a suicidal crisis. Methods. Event-related potentials were recorded during an emotional Go/NoGo task in 12 adolescents who attempted suicide and 12 age- and sex-matched healthy controls. Results. Compared to the control group, the suicidal group showed significantly reduced positivity at the time of the P3d (difference waveform reflecting NoGo minus Go trials) in response to happy and neutral, but not sad stimuli. For happy stimuli, this group difference was restricted to the right hemisphere. Further analyses indicated that the suicidal group had a reversed pattern of P3 amplitude in response to inhibition, with lower amplitudes in the NoGo compared to the Go conditions. Suicidal symptoms severity strongly correlated with lower amplitude of the P3d in response to neutral faces. Conclusions. These findings provide more insight into inhibition difficulties in adolescents with acute suicidal risk. Interactions between emotional and inhibition processing should be considered when treating acutely suicidal youths.

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青少年急性自杀危机反应抑制的情绪调节:情绪去/不去任务中的事件相关电位。
目标。自杀是青少年死亡的第二大原因,可能与抑制和情绪处理困难有关。本研究评估了因自杀危机住院的青少年情绪处理过程中认知抑制的神经相关。方法。在12名企图自杀的青少年和12名年龄和性别匹配的健康对照者的情绪Go/NoGo任务中记录事件相关电位。结果。与对照组相比,自杀组在P3d(反映NoGo - Go试验的差异波形)时对快乐和中性刺激的积极性显著降低,但对悲伤刺激没有反应。对于快乐刺激,这种组间差异仅限于右半球。进一步的分析表明,自杀组的P3波幅对抑制的反应是相反的,与Go条件相比,NoGo条件下的波幅更低。自杀症状的严重程度与对中性面孔反应的P3d振幅较低密切相关。结论。这些发现对有急性自杀风险的青少年的抑制困难提供了更多的见解。在治疗急性自杀青少年时,应考虑情绪和抑制加工之间的相互作用。
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来源期刊
Clinical EEG and Neuroscience
Clinical EEG and Neuroscience 医学-临床神经学
CiteScore
5.20
自引率
5.00%
发文量
66
审稿时长
>12 weeks
期刊介绍: Clinical EEG and Neuroscience conveys clinically relevant research and development in electroencephalography and neuroscience. Original articles on any aspect of clinical neurophysiology or related work in allied fields are invited for publication.
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