Fenugreek seed powder protects mice against arsenic-induced neurobehavioral changes

IF 2.9 Q2 TOXICOLOGY Current Research in Toxicology Pub Date : 2023-01-01 DOI:10.1016/j.crtox.2023.100114

Jahidul Islam , Zohurul Islam , Nazmul Haque, Moriom Khatun, Farhadul Islam, Shakhawoat Hossain, Md Ashraful Hoque, Farjana Nikkon, Khaled Hossain, Zahangir Alam Saud

{"title":"Fenugreek seed powder protects mice against arsenic-induced neurobehavioral changes","authors":"Jahidul Islam , Zohurul Islam , Nazmul Haque, Moriom Khatun, Farhadul Islam, Shakhawoat Hossain, Md Ashraful Hoque, Farjana Nikkon, Khaled Hossain, Zahangir Alam Saud","doi":"10.1016/j.crtox.2023.100114","DOIUrl":null,"url":null,"abstract":"<div><p>The current study was designed to evaluate the protective effect of fenugreek seed powder against As-induced neurobehavioral and biochemical perturbations using a mouse model. Mice exposed to arsenic at 10 mg/kg body weight showed development of anxiety-like behavior and memory impairment compared to control mice in elevated plus maze and Morris water maze tests, respectively. A significantly decreased acetyl and butyrylcholinesterase, superoxide dismutase and glutathione reductase activities and brain-derived neurotrophic factor levels were found in the brain of arsenic-exposed mice compared to control mice. Interestingly, supplementation of fenugreek seed powder to arsenic-treated mice significantly restored the activity of cholinesterase and antioxidant enzymes (<em>e.g.</em> superoxide dismutase, glutathione reductase) as well as brain-derived neurotrophic factor levels in the brain tissue of arsenic-exposed mice. Consequently, reduced anxiety-like behavior, improved learning and memory were observed in fenugreek supplemented arsenic treated mice compared to only arsenic-exposed mice group. Thus, this study suggests that fenugreek seed powder reduces arsenic-induced neurotoxicity in mice.</p></div>","PeriodicalId":11236,"journal":{"name":"Current Research in Toxicology","volume":"5 ","pages":"Article 100114"},"PeriodicalIF":2.9000,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/c9/e7/main.PMC10404539.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Research in Toxicology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2666027X23000129","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"TOXICOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

The current study was designed to evaluate the protective effect of fenugreek seed powder against As-induced neurobehavioral and biochemical perturbations using a mouse model. Mice exposed to arsenic at 10 mg/kg body weight showed development of anxiety-like behavior and memory impairment compared to control mice in elevated plus maze and Morris water maze tests, respectively. A significantly decreased acetyl and butyrylcholinesterase, superoxide dismutase and glutathione reductase activities and brain-derived neurotrophic factor levels were found in the brain of arsenic-exposed mice compared to control mice. Interestingly, supplementation of fenugreek seed powder to arsenic-treated mice significantly restored the activity of cholinesterase and antioxidant enzymes (e.g. superoxide dismutase, glutathione reductase) as well as brain-derived neurotrophic factor levels in the brain tissue of arsenic-exposed mice. Consequently, reduced anxiety-like behavior, improved learning and memory were observed in fenugreek supplemented arsenic treated mice compared to only arsenic-exposed mice group. Thus, this study suggests that fenugreek seed powder reduces arsenic-induced neurotoxicity in mice.

Abstract Image

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

胡芦巴籽粉保护小鼠免受砷诱导的神经行为改变

本研究旨在使用小鼠模型评估胡芦巴种子粉末对砷诱导的神经行为和生物化学扰动的保护作用。与对照小鼠相比，暴露于10mg/kg体重的砷的小鼠在升高的plus迷宫和Morris水迷宫测试中分别表现出焦虑样行为和记忆障碍的发展。与对照小鼠相比，在砷暴露小鼠的大脑中发现乙酰和丁酰胆碱酯酶、超氧化物歧化酶和谷胱甘肽还原酶活性以及脑源性神经营养因子水平显著降低。有趣的是，向砷处理的小鼠补充胡芦巴籽粉显著恢复了砷暴露小鼠脑组织中胆碱酯酶和抗氧化酶（如超氧化物歧化酶、谷胱甘肽还原酶）的活性以及脑源性神经营养因子的水平。因此，与仅接触砷的小鼠组相比，胡芦巴补充砷处理的小鼠观察到焦虑样行为减少，学习和记忆改善。因此，这项研究表明胡芦巴种子粉末可以减少砷对小鼠的神经毒性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊