Retinal Vascular Density Change in Patients With Aortic Valve Regurgitation.

IF 1.4 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS Cardiology Research Pub Date : 2023-08-01 DOI:10.14740/cr1502

Caner Topaloglu, Sinan Bilgin

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Abstract

Background: The aim of this study was to assess retinal vessel density in the superficial capillary plexus layer, deep capillary plexus layer and choriocapillaris plexus layer in patients with aortic valve regurgitation (AR) using optical coherence tomography angiography (OCTA).

Methods: Thirty-eight healthy participants (group 1) and 38 patients with AR (group 2) were assessed for this study. Diagnosis of AR is made by transthoracic echocardiography (TTE). Severity of AR was assessed according to values in the 2014 American Heart Association/American College of Cardiology (AHA/ACC) valve guideline. Superficial capillary plexus density (SCPD), deep capillary plexus density (DCPD) and choriocapillaris plexus density (CCPD) were analyzed between groups using OCTA.

Results: SCPD measurements were found to be decreased in the nasal, inferior and central regions of patients with AR (P ≤ 0.05). DCPD measurements were found to be decreased in the nasal and inferior regions of patients with AR (P ≤ 0.05). CCPD measurements were found to be decreased in the inferior and central regions of patients with AR (P ≤ 0.05). In patients with AR, CCPD measurements were significantly decreased in the inferior region compared to the control group. Central macular thickness was found to be significantly decreased in the patients with AR.

Conclusions: Patients with AR showed decreased flow density compared with healthy controls. Retinal perfusion measured using OCTA in patients with AR may give an idea about microperfusion.

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主动脉瓣反流患者视网膜血管密度的变化。

背景:本研究的目的是利用光学相干断层血管造影(OCTA)评估主动脉瓣反流(AR)患者的浅毛细血管丛层、深毛细血管丛层和绒毛膜毛细血管丛层视网膜血管密度。方法:对38名健康受试者(第一组)和38名AR患者(第二组)进行评估。经胸超声心动图(TTE)诊断AR。根据2014年美国心脏协会/美国心脏病学会(AHA/ACC)瓣膜指南中的值评估AR的严重程度。OCTA分析各组间浅毛丛密度(SCPD)、深毛丛密度(DCPD)和绒毛膜丛密度(CCPD)。结果:AR患者鼻、下、中央区SCPD测量值降低(P≤0.05)。AR患者鼻区和下区DCPD测量值降低(P≤0.05)。AR患者的下、中心区CCPD测量值降低(P≤0.05)。在AR患者中，与对照组相比，下区CCPD测量值显着降低。结论:与健康对照相比，AR患者的血流密度明显降低。使用OCTA测量AR患者的视网膜灌注可能对微灌注有一定的了解。

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来源期刊

Cardiology Research CARDIAC & CARDIOVASCULAR SYSTEMS-

CiteScore

2.50

自引率

0.00%

发文量

期刊介绍： Cardiology Research is an open access, peer-reviewed, international journal. All submissions relating to basic research and clinical practice of cardiology and cardiovascular medicine are in this journal''s scope. This journal focuses on publishing original research and observations in all cardiovascular medicine aspects. Manuscript types include original article, review, case report, short communication, book review, letter to the editor.