Scleromyxedema in an adult following Sinopharm BBIBP-CorV vaccination: An extremely rare phenomenon.

IF 1.4 Q3 RHEUMATOLOGY Journal of Scleroderma and Related Disorders Pub Date : 2023-06-01 Epub Date: 2022-06-30 DOI:10.1177/23971983221107321

Amirhossein Parsaei, Somayeh Sadat Rezaei, Alireza Rahmani, Maryam Masoumi, Hojat Dehghanbanadaki, Somayyeh Norouzi, Mohammad Mehdi Riyahi, Reihane Tabaraii, Seyed Mohammad Hashem Montazeri

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Abstract

Introduction: The Sinopharm BBIBP-CorV vaccine produces a variety of cutaneous adverse effects. Scleromyxedema is a mucinous connective tissue disorder that causes skin thickness and sclerodermoid changes. According to our findings, this is the first case of scleromyxedema induced by the Sinopharm immunization.

Case description: We discuss the case of a 75-year-old woman who acquired progressive thickening of the skin in her limbs and trunk after getting the Sinopharm vaccination. Examination, laboratory testing, and a biopsy were used to verify scleromyxedema diagnosis. Intravenous immunoglobulins, mycophenolate mofetil, and prednisolone were used in the treatment of the patient. The outcomes from the 4-month follow-up were reassuring.

Conclusion: This study emphasizes the need of considering scleromyxedema as a connective tissue pathology in patients who have recently received Sinopharm vaccine and have similar cutaneous signs.

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一名成人接种国药集团 BBIBP-CorV 疫苗后出现硬化性水肿：一种极为罕见的现象

简介国药集团 BBIBP-CorV 疫苗会产生多种皮肤不良反应。硬肿症是一种粘液结缔组织疾病，会导致皮肤增厚和硬皮样改变。根据我们的研究结果，这是首例由国药集团免疫接种诱发的硬皮水肿病例：我们讨论的病例是一名 75 岁的妇女在接种国药控股疫苗后出现四肢和躯干皮肤进行性增厚。通过检查、实验室检测和活组织切片验证了硬肌水肿的诊断。患者接受了静脉注射免疫球蛋白、霉酚酸酯和泼尼松龙治疗。4 个月的随访结果令人欣慰：本研究强调，对于近期接种过国药准字疫苗并有类似皮肤症状的患者，有必要将硬膜水肿视为结缔组织病变。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Journal of Scleroderma and Related Disorders RHEUMATOLOGY-

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4.10

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